Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis
<h2>Purpose</h2> <p>Periprosthetic joint infection (PJI) is one of the most debilitating complications following joint replacement surgery. Synovial biomarkers, such as Calprotectin, have become valuable in the diagnosis of PJI. This meta-analysis aimed to investigate the role of s...
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2022
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| _version_ | 1864513568067551232 |
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| author | Ashraf T. Hantouly (14150319) |
| author2 | Motasem Salameh (14146794) Ahmad A. Toubasi (12252185) Loay A. Salman (14150322) Osama Alzobi (14150292) Abdulaziz F. Ahmed (14150082) Shamsi Hameed (14150325) Bashir Zikria (14150328) Ghalib Ahmed (14146800) |
| author2_role | author author author author author author author author |
| author_facet | Ashraf T. Hantouly (14150319) Motasem Salameh (14146794) Ahmad A. Toubasi (12252185) Loay A. Salman (14150322) Osama Alzobi (14150292) Abdulaziz F. Ahmed (14150082) Shamsi Hameed (14150325) Bashir Zikria (14150328) Ghalib Ahmed (14146800) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ashraf T. Hantouly (14150319) Motasem Salameh (14146794) Ahmad A. Toubasi (12252185) Loay A. Salman (14150322) Osama Alzobi (14150292) Abdulaziz F. Ahmed (14150082) Shamsi Hameed (14150325) Bashir Zikria (14150328) Ghalib Ahmed (14146800) |
| dc.date.none.fl_str_mv | 2022-11-22T21:12:01Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00264-022-05357-6 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Synovial_fluid_calprotectin_in_diagnosing_periprosthetic_joint_infection_A_meta-analysis/21596985 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical sciences Orthopedics and Sports Medicine Surgery |
| dc.title.none.fl_str_mv | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Purpose</h2> <p>Periprosthetic joint infection (PJI) is one of the most debilitating complications following joint replacement surgery. Synovial biomarkers, such as Calprotectin, have become valuable in the diagnosis of PJI. This meta-analysis aimed to investigate the role of synovial Calprotectin as a diagnostic test in PJI.</p> <h2>Methods</h2> <p>This meta-analysis was conducted with adherence to PRISMA guidelines. PubMed, Cochrane, Web of Science, and Google Scholar were searched until February 2022. Inclusion criteria were as follows: all studies in which the patients with joint replacements were evaluated for PJI; synovial Calprotectin was the biomarker of choice to diagnose PJI; standardized guidelines were used as the gold standard for the diagnosis; and a comparison between the guidelines and Calprotectin results was made. Diagnostic parameters such as sensitivity, specificity, diagnostic odds ratio (DOR), positive predictive value, negative predictive value, and area under the curve (AUC) were calculated for the included studies to evaluate synovial Calprotectin for PJI diagnosis.</p> <h2>Results</h2> <p>The total number of the included patients was 618 from eight studies. The pooled sensitivity, specificity, and diagnostic odds ratio of Calprotectin test were 92% (95%CI: 84%-98%), 93% (95%CI: 84%-99%), and 187.61 (95%CI: 20.21–1741.18), respectively. The results showed that the negative and positive likelihood ratios of the Calprotectin test were 0.07 (95%CI: 0.02–0.22) and 9.91 (95%CI: 4.11–23.93), respectively. The SROC showed that the area under the curve for Calprotectin test was 0.935.</p> <h2>Conclusion</h2> <p>Synovial Calprotectin is a valuable biomarker as it provides a reliable and rapid diagnosis of PJI. It has the potential to be used in clinical practice due to its high sensitivity and specificity that are comparable to the other utilized biomarkers. Another advantage is its low cost relative to other biomarkers.</p><h2>Other Information</h2> <p> Published in: International Orthopaedics<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00264-022-05357-6" target="_blank">http://dx.doi.org/10.1007/s00264-022-05357-6</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ff1b74ba01f6fc50cd227cda4da09cd6 |
| identifier_str_mv | 10.1007/s00264-022-05357-6 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21596985 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysisAshraf T. Hantouly (14150319)Motasem Salameh (14146794)Ahmad A. Toubasi (12252185)Loay A. Salman (14150322)Osama Alzobi (14150292)Abdulaziz F. Ahmed (14150082)Shamsi Hameed (14150325)Bashir Zikria (14150328)Ghalib Ahmed (14146800)Clinical sciencesOrthopedics and Sports MedicineSurgery<h2>Purpose</h2> <p>Periprosthetic joint infection (PJI) is one of the most debilitating complications following joint replacement surgery. Synovial biomarkers, such as Calprotectin, have become valuable in the diagnosis of PJI. This meta-analysis aimed to investigate the role of synovial Calprotectin as a diagnostic test in PJI.</p> <h2>Methods</h2> <p>This meta-analysis was conducted with adherence to PRISMA guidelines. PubMed, Cochrane, Web of Science, and Google Scholar were searched until February 2022. Inclusion criteria were as follows: all studies in which the patients with joint replacements were evaluated for PJI; synovial Calprotectin was the biomarker of choice to diagnose PJI; standardized guidelines were used as the gold standard for the diagnosis; and a comparison between the guidelines and Calprotectin results was made. Diagnostic parameters such as sensitivity, specificity, diagnostic odds ratio (DOR), positive predictive value, negative predictive value, and area under the curve (AUC) were calculated for the included studies to evaluate synovial Calprotectin for PJI diagnosis.</p> <h2>Results</h2> <p>The total number of the included patients was 618 from eight studies. The pooled sensitivity, specificity, and diagnostic odds ratio of Calprotectin test were 92% (95%CI: 84%-98%), 93% (95%CI: 84%-99%), and 187.61 (95%CI: 20.21–1741.18), respectively. The results showed that the negative and positive likelihood ratios of the Calprotectin test were 0.07 (95%CI: 0.02–0.22) and 9.91 (95%CI: 4.11–23.93), respectively. The SROC showed that the area under the curve for Calprotectin test was 0.935.</p> <h2>Conclusion</h2> <p>Synovial Calprotectin is a valuable biomarker as it provides a reliable and rapid diagnosis of PJI. It has the potential to be used in clinical practice due to its high sensitivity and specificity that are comparable to the other utilized biomarkers. Another advantage is its low cost relative to other biomarkers.</p><h2>Other Information</h2> <p> Published in: International Orthopaedics<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00264-022-05357-6" target="_blank">http://dx.doi.org/10.1007/s00264-022-05357-6</a></p>2022-11-22T21:12:01ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00264-022-05357-6https://figshare.com/articles/journal_contribution/Synovial_fluid_calprotectin_in_diagnosing_periprosthetic_joint_infection_A_meta-analysis/21596985CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215969852022-11-22T21:12:01Z |
| spellingShingle | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis Ashraf T. Hantouly (14150319) Clinical sciences Orthopedics and Sports Medicine Surgery |
| status_str | publishedVersion |
| title | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis |
| title_full | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis |
| title_fullStr | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis |
| title_full_unstemmed | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis |
| title_short | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis |
| title_sort | Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis |
| topic | Clinical sciences Orthopedics and Sports Medicine Surgery |