The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome
<p dir="ltr">Our study objective was to assess the effect of various sperm DNA fragmentation levels on clinical intracytoplasmic sperm injection outcome. This retrospective study included 392 patients who underwent ICSI and performed sperm DNA fragmentation testing before the procedu...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2021
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513555780337664 |
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| author | Kareim Khalafalla (14148807) |
| author2 | Ahmad Majzoub (14058045) Haitham Elbardisi (14058048) Ashni Bhathella (14779228) Arth Chaudhari (14779231) Ashok Agarwal (325619) Ralf Henkel (8192964) Thoraya AlMarzooki (14779234) Hasan Burjaq (13036446) Mohamed Arafa (14058042) |
| author2_role | author author author author author author author author author |
| author_facet | Kareim Khalafalla (14148807) Ahmad Majzoub (14058045) Haitham Elbardisi (14058048) Ashni Bhathella (14779228) Arth Chaudhari (14779231) Ashok Agarwal (325619) Ralf Henkel (8192964) Thoraya AlMarzooki (14779234) Hasan Burjaq (13036446) Mohamed Arafa (14058042) |
| author_role | author |
| dc.creator.none.fl_str_mv | Kareim Khalafalla (14148807) Ahmad Majzoub (14058045) Haitham Elbardisi (14058048) Ashni Bhathella (14779228) Arth Chaudhari (14779231) Ashok Agarwal (325619) Ralf Henkel (8192964) Thoraya AlMarzooki (14779234) Hasan Burjaq (13036446) Mohamed Arafa (14058042) |
| dc.date.none.fl_str_mv | 2021-07-11T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/and.14180 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_effect_of_sperm_DNA_fragmentation_on_intracytoplasmic_sperm_injection_outcome/22258438 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Reproductive medicine clinical reproductive outcomes intracytoplasmic sperm injection sperm chromatin dispersion test sperm DNA fragmentation |
| dc.title.none.fl_str_mv | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Our study objective was to assess the effect of various sperm DNA fragmentation levels on clinical intracytoplasmic sperm injection outcome. This retrospective study included 392 patients who underwent ICSI and performed sperm DNA fragmentation testing before the procedure. Based on sperm DNA fragmentation cut-off values, the patients were differentiated into 3 groups as <20%, 20%–30% and >30%. According to the female status, patients were differentiated into favourable group (<i>n</i> = 259) with female age <35 years and anti-Mullerian hormone level ≥7.1 pmol/L; and unfavourable group (<i>n</i> = 133) with female age ≥35 years and anti-Mullerian hormone level ≤7.1 pmol/L. The patient's medical records were reviewed, and patient's demographic, laboratory data including semen analysis, sperm DNA fragmentation determined by means of sperm chromatin dispersion, hormonal profile and data regarding intracytoplasmic sperm injection cycle were collected. This cohort reported that the clinical reproductive outcomes of intracytoplasmic sperm injection showed no statistical significance with increase sperm DNA fragmentation levels. In sperm DNA fragmentation above 30%, favourable females had significantly higher clinical pregnancy rate and live birth rate than unfavourable females, while fertilisation rate and miscarriage rate showed no significance between the subgroups. High sperm DNA fragmentation is linked to poor semen parameters.</p><h2>Other Information</h2><p dir="ltr">Published in: Andrologia<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/and.14180" target="_blank">http://dx.doi.org/10.1111/and.14180</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ff4402a499a7618c4bbceee990674790 |
| identifier_str_mv | 10.1111/and.14180 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22258438 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcomeKareim Khalafalla (14148807)Ahmad Majzoub (14058045)Haitham Elbardisi (14058048)Ashni Bhathella (14779228)Arth Chaudhari (14779231)Ashok Agarwal (325619)Ralf Henkel (8192964)Thoraya AlMarzooki (14779234)Hasan Burjaq (13036446)Mohamed Arafa (14058042)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesReproductive medicineclinical reproductive outcomesintracytoplasmic sperm injectionsperm chromatin dispersion testsperm DNA fragmentation<p dir="ltr">Our study objective was to assess the effect of various sperm DNA fragmentation levels on clinical intracytoplasmic sperm injection outcome. This retrospective study included 392 patients who underwent ICSI and performed sperm DNA fragmentation testing before the procedure. Based on sperm DNA fragmentation cut-off values, the patients were differentiated into 3 groups as <20%, 20%–30% and >30%. According to the female status, patients were differentiated into favourable group (<i>n</i> = 259) with female age <35 years and anti-Mullerian hormone level ≥7.1 pmol/L; and unfavourable group (<i>n</i> = 133) with female age ≥35 years and anti-Mullerian hormone level ≤7.1 pmol/L. The patient's medical records were reviewed, and patient's demographic, laboratory data including semen analysis, sperm DNA fragmentation determined by means of sperm chromatin dispersion, hormonal profile and data regarding intracytoplasmic sperm injection cycle were collected. This cohort reported that the clinical reproductive outcomes of intracytoplasmic sperm injection showed no statistical significance with increase sperm DNA fragmentation levels. In sperm DNA fragmentation above 30%, favourable females had significantly higher clinical pregnancy rate and live birth rate than unfavourable females, while fertilisation rate and miscarriage rate showed no significance between the subgroups. High sperm DNA fragmentation is linked to poor semen parameters.</p><h2>Other Information</h2><p dir="ltr">Published in: Andrologia<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1111/and.14180" target="_blank">http://dx.doi.org/10.1111/and.14180</a></p>2021-07-11T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/and.14180https://figshare.com/articles/journal_contribution/The_effect_of_sperm_DNA_fragmentation_on_intracytoplasmic_sperm_injection_outcome/22258438CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222584382021-07-11T06:00:00Z |
| spellingShingle | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome Kareim Khalafalla (14148807) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Reproductive medicine clinical reproductive outcomes intracytoplasmic sperm injection sperm chromatin dispersion test sperm DNA fragmentation |
| status_str | publishedVersion |
| title | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome |
| title_full | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome |
| title_fullStr | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome |
| title_full_unstemmed | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome |
| title_short | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome |
| title_sort | The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Reproductive medicine clinical reproductive outcomes intracytoplasmic sperm injection sperm chromatin dispersion test sperm DNA fragmentation |