The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
<p dir="ltr">Rheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30–45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors that drive loss of immunological tolerance. The...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2023
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| _version_ | 1864513507702079488 |
|---|---|
| author | Amira Kohil (15257285) |
| author2 | Wafa Abdalla (19437994) Wisam N. Ibrahim (19437997) Khalid M. Al-Harbi (19438000) Amal Al-Haidose (19438003) Maha Al-Asmakh (614593) Atiyeh M. Abdallah (10742523) |
| author2_role | author author author author author author |
| author_facet | Amira Kohil (15257285) Wafa Abdalla (19437994) Wisam N. Ibrahim (19437997) Khalid M. Al-Harbi (19438000) Amal Al-Haidose (19438003) Maha Al-Asmakh (614593) Atiyeh M. Abdallah (10742523) |
| author_role | author |
| dc.creator.none.fl_str_mv | Amira Kohil (15257285) Wafa Abdalla (19437994) Wisam N. Ibrahim (19437997) Khalid M. Al-Harbi (19438000) Amal Al-Haidose (19438003) Maha Al-Asmakh (614593) Atiyeh M. Abdallah (10742523) |
| dc.date.none.fl_str_mv | 2023-09-08T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/medicina59091629 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Immunomodulatory_Role_of_Microbiota_in_Rheumatic_Heart_Disease_What_Do_We_Know_and_What_Can_We_Learn_from_Other_Rheumatic_Diseases_/26772160 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Immunology rheumatic heart disease microbiota immunomodulation autoimmunity molecular mimicry epitope spreading bystander activation |
| dc.title.none.fl_str_mv | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Rheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30–45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors that drive loss of immunological tolerance. The gut and oral microbiome have recently been implicated in the pathogenesis of RHD. Disruption of the delicate balance of the microbiome, or dysbiosis, is thought to lead to autoimmune responses through several different mechanisms including molecular mimicry, epitope spreading, and bystander activation. However, data on the microbiomes of RHD patients are scarce. Therefore, in this comprehensive review, we explore the various dimensions of the intricate relationship between the microbiome and the immune system in RHD and other rheumatic diseases to explore the potential effect of microbiota on RHD and opportunities for diagnosis and treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicina<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/medicina59091629" target="_blank">https://dx.doi.org/10.3390/medicina59091629</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_ffc8e2a7ede78937f680bbf904bed901 |
| identifier_str_mv | 10.3390/medicina59091629 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26772160 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?Amira Kohil (15257285)Wafa Abdalla (19437994)Wisam N. Ibrahim (19437997)Khalid M. Al-Harbi (19438000)Amal Al-Haidose (19438003)Maha Al-Asmakh (614593)Atiyeh M. Abdallah (10742523)Biomedical and clinical sciencesCardiovascular medicine and haematologyImmunologyrheumatic heart diseasemicrobiotaimmunomodulationautoimmunitymolecular mimicryepitope spreadingbystander activation<p dir="ltr">Rheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30–45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors that drive loss of immunological tolerance. The gut and oral microbiome have recently been implicated in the pathogenesis of RHD. Disruption of the delicate balance of the microbiome, or dysbiosis, is thought to lead to autoimmune responses through several different mechanisms including molecular mimicry, epitope spreading, and bystander activation. However, data on the microbiomes of RHD patients are scarce. Therefore, in this comprehensive review, we explore the various dimensions of the intricate relationship between the microbiome and the immune system in RHD and other rheumatic diseases to explore the potential effect of microbiota on RHD and opportunities for diagnosis and treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicina<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/medicina59091629" target="_blank">https://dx.doi.org/10.3390/medicina59091629</a></p>2023-09-08T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/medicina59091629https://figshare.com/articles/journal_contribution/The_Immunomodulatory_Role_of_Microbiota_in_Rheumatic_Heart_Disease_What_Do_We_Know_and_What_Can_We_Learn_from_Other_Rheumatic_Diseases_/26772160CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/267721602023-09-08T03:00:00Z |
| spellingShingle | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases? Amira Kohil (15257285) Biomedical and clinical sciences Cardiovascular medicine and haematology Immunology rheumatic heart disease microbiota immunomodulation autoimmunity molecular mimicry epitope spreading bystander activation |
| status_str | publishedVersion |
| title | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases? |
| title_full | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases? |
| title_fullStr | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases? |
| title_full_unstemmed | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases? |
| title_short | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases? |
| title_sort | The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases? |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Immunology rheumatic heart disease microbiota immunomodulation autoimmunity molecular mimicry epitope spreading bystander activation |