ADEPT core and adaptive components.
<div><p>Background</p><p>There is limited evidence to assess if interventions implemented during pregnancy proactively mitigate parental vaccine hesitancy and promote timely vaccination among children after birth. This study protocol describes the evaluation of an ADaptivE Pr...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1852024998155255808 |
|---|---|
| author | Lavanya Vasudevan (6916850) |
| author2 | Rachael M. Porter (10214021) Ilse Campos (20308705) Elizabeth L. Turner (7886783) Sandra S. Stinnett (4840368) Leah L. Zullig (8633637) Emmanuel B. Walter (15190057) Geeta K. Swamy (6911534) Robert A Bednarczyk (20308708) Walter A. Orenstein (4276135) Beverly Gray (20308711) |
| author2_role | author author author author author author author author author author |
| author_facet | Lavanya Vasudevan (6916850) Rachael M. Porter (10214021) Ilse Campos (20308705) Elizabeth L. Turner (7886783) Sandra S. Stinnett (4840368) Leah L. Zullig (8633637) Emmanuel B. Walter (15190057) Geeta K. Swamy (6911534) Robert A Bednarczyk (20308708) Walter A. Orenstein (4276135) Beverly Gray (20308711) |
| author_role | author |
| dc.creator.none.fl_str_mv | Lavanya Vasudevan (6916850) Rachael M. Porter (10214021) Ilse Campos (20308705) Elizabeth L. Turner (7886783) Sandra S. Stinnett (4840368) Leah L. Zullig (8633637) Emmanuel B. Walter (15190057) Geeta K. Swamy (6911534) Robert A Bednarczyk (20308708) Walter A. Orenstein (4276135) Beverly Gray (20308711) |
| dc.date.none.fl_str_mv | 2024-11-21T19:01:38Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0313742.g002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/ADEPT_core_and_adaptive_components_/27885182 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Cell Biology Biotechnology Sociology Cancer Science Policy Infectious Diseases Biological Sciences not elsewhere classified time pregnant individuals state immunization registry promote timely vaccinations part training program increasing childhood vaccinations increase childhood vaccinations routine prenatal visit timely childhood vaccination xlink "> within type 1 effectiveness parental vaccine hesitancy offered adaptive components discuss vaccines recommended child &# 8217 primary study outcome post intervention change study protocol describes pis give birth cluster randomized trial childhood vaccines xlink "> adaptive prenatal secondary outcome randomized trial offered enrollment discuss concerns assessed post vaccination outcomes vaccination intention prenatal interventions study protocol study practices study findings vaccine navigator phone call limited evidence intervention sites hesitant pis effective communication educational website control arms contribute evidence 2 months |
| dc.title.none.fl_str_mv | ADEPT core and adaptive components. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <div><p>Background</p><p>There is limited evidence to assess if interventions implemented during pregnancy proactively mitigate parental vaccine hesitancy and promote timely vaccination among children after birth. This study protocol describes the evaluation of an ADaptivE PrenaTal (ADEPT) intervention to increase childhood vaccinations that is implemented with first-time pregnant individuals (PIs).</p><p>Methods</p><p>Within the framework of a type 1 effectiveness-implementation hybrid study design, a cluster-randomized trial (CRT) will determine the effectiveness of ADEPT at increasing childhood vaccinations, and a nested explanatory mixed methods (NMM) study will assess changes in parental vaccine hesitancy. Study practices will be randomized to deliver ADEPT in addition to standard of care or standard of care alone. Providers at intervention sites will participate in a 4-part training program on childhood vaccines and effective communication. During a routine prenatal visit, providers will discuss vaccines recommended for the PI during pregnancy and for the child after birth, following which PIs will be screened for vaccination intention. Vaccine-hesitant PIs will be offered adaptive components of the intervention, which include an educational website and phone call with a vaccine navigator to discuss concerns. They will also be offered enrollment into the NMM study, where their vaccination intention will be assessed post-intervention. After PIs give birth, their child’s vaccination outcomes at 2 months will be extracted from the state immunization registry. The primary study outcome is the difference in timely childhood vaccination at 2 months between the intervention and control arms. The secondary outcome is reduction in vaccine hesitancy assessed among PIs in the NMM study as the pre-post intervention change in vaccination intention.</p><p>Discussion</p><p>The study findings are expected to contribute evidence on the effectiveness of prenatal interventions to proactively mitigate parental vaccine hesitancy and promote timely vaccinations after the child’s birth.</p><p>Trial registration</p><p>The study protocol is registered in ClinicalTrials.gov (<a href="https://clinicaltrials.gov/ct2/show/NCT05795855" target="_blank">NCT05795855</a>).</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_002e4e558740c16c4d41668bdd4e7d96 |
| identifier_str_mv | 10.1371/journal.pone.0313742.g002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27885182 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | ADEPT core and adaptive components.Lavanya Vasudevan (6916850)Rachael M. Porter (10214021)Ilse Campos (20308705)Elizabeth L. Turner (7886783)Sandra S. Stinnett (4840368)Leah L. Zullig (8633637)Emmanuel B. Walter (15190057)Geeta K. Swamy (6911534)Robert A Bednarczyk (20308708)Walter A. Orenstein (4276135)Beverly Gray (20308711)MedicineCell BiologyBiotechnologySociologyCancerScience PolicyInfectious DiseasesBiological Sciences not elsewhere classifiedtime pregnant individualsstate immunization registrypromote timely vaccinationspart training programincreasing childhood vaccinationsincrease childhood vaccinationsroutine prenatal visittimely childhood vaccinationxlink "> withintype 1 effectivenessparental vaccine hesitancyoffered adaptive componentsdiscuss vaccines recommendedchild &# 8217primary study outcomepost intervention changestudy protocol describespis give birthcluster randomized trialchildhood vaccinesxlink ">adaptive prenatalsecondary outcomerandomized trialoffered enrollmentdiscuss concernsassessed postvaccination outcomesvaccination intentionprenatal interventionsstudy protocolstudy practicesstudy findingsvaccine navigatorphone calllimited evidenceintervention siteshesitant piseffective communicationeducational websitecontrol armscontribute evidence2 months<div><p>Background</p><p>There is limited evidence to assess if interventions implemented during pregnancy proactively mitigate parental vaccine hesitancy and promote timely vaccination among children after birth. This study protocol describes the evaluation of an ADaptivE PrenaTal (ADEPT) intervention to increase childhood vaccinations that is implemented with first-time pregnant individuals (PIs).</p><p>Methods</p><p>Within the framework of a type 1 effectiveness-implementation hybrid study design, a cluster-randomized trial (CRT) will determine the effectiveness of ADEPT at increasing childhood vaccinations, and a nested explanatory mixed methods (NMM) study will assess changes in parental vaccine hesitancy. Study practices will be randomized to deliver ADEPT in addition to standard of care or standard of care alone. Providers at intervention sites will participate in a 4-part training program on childhood vaccines and effective communication. During a routine prenatal visit, providers will discuss vaccines recommended for the PI during pregnancy and for the child after birth, following which PIs will be screened for vaccination intention. Vaccine-hesitant PIs will be offered adaptive components of the intervention, which include an educational website and phone call with a vaccine navigator to discuss concerns. They will also be offered enrollment into the NMM study, where their vaccination intention will be assessed post-intervention. After PIs give birth, their child’s vaccination outcomes at 2 months will be extracted from the state immunization registry. The primary study outcome is the difference in timely childhood vaccination at 2 months between the intervention and control arms. The secondary outcome is reduction in vaccine hesitancy assessed among PIs in the NMM study as the pre-post intervention change in vaccination intention.</p><p>Discussion</p><p>The study findings are expected to contribute evidence on the effectiveness of prenatal interventions to proactively mitigate parental vaccine hesitancy and promote timely vaccinations after the child’s birth.</p><p>Trial registration</p><p>The study protocol is registered in ClinicalTrials.gov (<a href="https://clinicaltrials.gov/ct2/show/NCT05795855" target="_blank">NCT05795855</a>).</p></div>2024-11-21T19:01:38ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0313742.g002https://figshare.com/articles/figure/ADEPT_core_and_adaptive_components_/27885182CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/278851822024-11-21T19:01:38Z |
| spellingShingle | ADEPT core and adaptive components. Lavanya Vasudevan (6916850) Medicine Cell Biology Biotechnology Sociology Cancer Science Policy Infectious Diseases Biological Sciences not elsewhere classified time pregnant individuals state immunization registry promote timely vaccinations part training program increasing childhood vaccinations increase childhood vaccinations routine prenatal visit timely childhood vaccination xlink "> within type 1 effectiveness parental vaccine hesitancy offered adaptive components discuss vaccines recommended child &# 8217 primary study outcome post intervention change study protocol describes pis give birth cluster randomized trial childhood vaccines xlink "> adaptive prenatal secondary outcome randomized trial offered enrollment discuss concerns assessed post vaccination outcomes vaccination intention prenatal interventions study protocol study practices study findings vaccine navigator phone call limited evidence intervention sites hesitant pis effective communication educational website control arms contribute evidence 2 months |
| status_str | publishedVersion |
| title | ADEPT core and adaptive components. |
| title_full | ADEPT core and adaptive components. |
| title_fullStr | ADEPT core and adaptive components. |
| title_full_unstemmed | ADEPT core and adaptive components. |
| title_short | ADEPT core and adaptive components. |
| title_sort | ADEPT core and adaptive components. |
| topic | Medicine Cell Biology Biotechnology Sociology Cancer Science Policy Infectious Diseases Biological Sciences not elsewhere classified time pregnant individuals state immunization registry promote timely vaccinations part training program increasing childhood vaccinations increase childhood vaccinations routine prenatal visit timely childhood vaccination xlink "> within type 1 effectiveness parental vaccine hesitancy offered adaptive components discuss vaccines recommended child &# 8217 primary study outcome post intervention change study protocol describes pis give birth cluster randomized trial childhood vaccines xlink "> adaptive prenatal secondary outcome randomized trial offered enrollment discuss concerns assessed post vaccination outcomes vaccination intention prenatal interventions study protocol study practices study findings vaccine navigator phone call limited evidence intervention sites hesitant pis effective communication educational website control arms contribute evidence 2 months |