Application of STUPPIT to identify novel intermediary proteins between SMAD4 and β-catenin, central hubs of BMP and Wnt pathway.

Application of STUPPIT to identify novel intermediary proteins between SMAD4 and β-catenin, central hubs of BMP and Wnt pathway.

<p><b>(A)</b> Schematic of the opposing effects of BMP and Wnt signaling on stem cell behavior. <b>(B)</b> STUPPIT strategy for labeling proteins that bridge SMAD4 and β-catenin. <b>(C)</b> STUPPIT workflow for capturing intermediary proteins between SMAD4 a...

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Detalles Bibliográficos
Autor Principal: Lin Xie (136792) (author)
Outros autores: Lijuan Gao (5093777) (author), Weihong Fu (8430690) (author), Gangyun Wu (22676687) (author), Hua Li (46469) (author), Wenxiu Ning (18239607) (author)
Publicado: 2025
Subjects:
Biophysics
Biochemistry
Cell Biology
Genetics
Molecular Biology
Physiology
Biotechnology
Developmental Biology
Cancer
Inorganic Chemistry
Infectious Diseases
Plant Biology
Virology
Chemical Sciences not elsewhere classified
step enzymatic reaction
offering new insights
capturing intermediary proteins
capture intermediary proteins
biotinylate intermediary proteins
plit -< u
div >< p
labeling intermediary proteins
tu </ u
proximity labeling tools
proximity labeling tool
characterized protein triads
bmp signaling pathways
p </ u
bridge two non
</ u
signaling pathways
interacting proteins
tools available
powerful tool
two non
protein interactions
key components
interacting partners
identifying upstream
downstream effectors
disease pathogenesis
directly label
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