<b>Tau Degradome Foundation Atlas</b>
<p dir="ltr">The <i>Tau Degradome Foundation Atlas</i> (Version 1) is an open-access, curated resource of proteolytic peptides derived from tau protein isoforms relevant to neurodegeneration research. The dataset includes:</p><ul><li><b>Wild-type t...
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2025
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| Summary: | <p dir="ltr">The <i>Tau Degradome Foundation Atlas</i> (Version 1) is an open-access, curated resource of proteolytic peptides derived from tau protein isoforms relevant to neurodegeneration research. The dataset includes:</p><ul><li><b>Wild-type tau</b> (UniProt ID: P10636)</li><li><b>BigTau</b> [1]</li><li><b>Low molecular weight (lmw) tau</b> [1]</li><li><b>Tau_4A</b> [1]</li></ul><p dir="ltr">This atlas provides a comprehensive reference of proteolytic cleavage products of tau, annotated with chemical and biophysical features to support biomarker discovery, assay development, and translational neuroscience research [1].</p><p dir="ltr"><b>Key Features</b></p><ul><li><b>Unique BigTau peptides</b> are flagged (<code>unique_BigTau=1</code>) to aid in the identification of novel BigTau-specific biomarkers.</li><li><b>Thermodynamic stability</b> is predicted for each peptide, with stable candidates labelled (<code>stable=1</code>), highlighting their suitability for biomarker assay development.</li><li><b>Hydrophobicity and charge values</b> are provided to guide selection of peptides with favourable solubility profiles [2].</li><li><b>Proteolytic origin</b> is annotated for every peptide, including cleavage site information.</li><li><b>Data format:</b> All peptide annotations are provided as comma-delimited ASCII <code>.csv</code> files.</li><li><b>Convenience files:</b> Unique BigTau peptides are also provided separately as a compressed file (<code>BigTau-unique.csv</code>).</li><li><b>Compression format:</b> Datasets are distributed in <code>.tar.gz</code> format and can be extracted with:</li></ul><pre></pre><pre><code>tar -xvzf FILENAME.tar.gz</code><br><br></pre><p dir="ltr"><b>Reproducibility and Methods</b><br>All datasets can be fully regenerated using open-source software tools, including <b>Python</b> and <b>SAS</b>. To ensure transparency and reproducibility, the repository includes complete Python and SAS scripts with documentation, following the methodology described in [2].</p><p><br></p><p dir="ltr"><b>Applications</b></p><ul><li>Identification of tau-derived peptides for neurodegeneration biomarker discovery.</li><li>Development of chemically stable and water-soluble assay targets.</li><li>Exploration of the proteolytic landscape of tau isoforms for translational neuroscience.</li></ul><p dir="ltr"><b>References</b><br>[1] Fischer I. <i>Considering Big tau as a novel and specific biomarker for spinal motor neuron pathology.</i> Neurobiol Dis. 2025 Sep 23;216:107118. doi: <a href="" rel="noopener" target="_new">10.1016/j.nbd.2025.107118</a></p><p dir="ltr">[2] Petzold A. <i>Proteolysis-Based Biomarker Repertoire of the Neurofilament Proteome.</i> J Neurochem. 2025 Mar;169(3):e70023. doi: <a href="" rel="noopener" target="_new">10.1111/jnc.70023</a></p> |
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