Integration of lipid ratios with multi-omic datasets to explore ether lipid metabolism in obesity.
<p>Summary figure details changes in ether lipid metabolism in obesity as indicated by the lipid ratios, liver micro-array data, and GWAS analysis. Coloured text depicts potential changes in enzymatic activity (green: increase; red: decrease), identified through linear regression analysis, adj...
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2025
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| Summary: | <p>Summary figure details changes in ether lipid metabolism in obesity as indicated by the lipid ratios, liver micro-array data, and GWAS analysis. Coloured text depicts potential changes in enzymatic activity (green: increase; red: decrease), identified through linear regression analysis, adjusting for age and sex, of 82 lipid ratios and waist circumference in the AusDiab cohort (<i>n</i> = 10,399). Lipid ratios were log<sub>2</sub> transformed, mean-centered and scaled to standard deviation. <i><i>p-values</i></i> were corrected for multiple comparisons using the false discovery rate method of Benjamini and Hochberg. Scatter plots depict consolidated liver micro-array data of male mice across 74 matched strains (<i>n</i> = 2−3 per strain) after either a high-fat/high-sugar (navy, <i>n</i> = 152) or chow (blue, <i>n</i> = 222) diet for eight weeks. Data was log<sub>2</sub> transformed and analyzed using Mann–Whitney <i>U</i> tests; <i><i>****p < 0.0001</i></i>. Manhattan plots show associations between the PE(O)/PE(P) and PC(O)/PC(P) ratios and <i>TMEM189</i> and <i>TMEM229B</i> loci in the BHS cohort (<i>n</i> = 4,492), respectively. Orange text depicts the location of the proposed lyso-plasmalogenase <i>TMEM229b</i>. DHAP: dihydroxyacetone phosphate; <i>Gpd1</i>: glycerol-3-phosphate dehydrogenase 1 (encodes for G3pdh); <i><i>G3pdh</i></i>: glycerol-3-phosphate dehydrogenase; DG: diacylglycerol; TG: triacylglycerol; PE: phosphatidylethanolamine; PC: phosphatidylcholine; <i><i>Gnpat</i></i>: glyceronephosphate O-acyltransferase; <i><i>Adhap-S</i></i>: alkyl-dihydroxyacetone phosphate synthase; <i><i>Far1</i></i>: fatty acyl-CoA reductase 1; <i><i>Far2</i></i>: fatty acyl-CoA reductase 2; <i><i>Tmem189</i></i>: transmembrane protein 189 (encodes for <i><i>Peds1</i></i>); <i><i>Peds1</i></i>: plasmanylethanolamine-desaturase-1; <i><i>Plc</i></i>: phospholipase C; <i><i>Pemt</i></i>: phosphatidylethanolamine N-methyltransferase; <i><i>C-pt</i></i>: choline phosphotransferase; <i><i>Pla2g6</i></i>: phospholipase A2 group VI (encodes for <i><i>iPla2</i></i>); <i><i>iPla2</i></i>: i-phospholipase A2, calcium independent phospholipase A2; <i><i>Lpeat3</i></i>: lyso-phosphatidylethanolamine acyltransferase 3; <i><i>Lpcat3:</i></i> lyso-phosphatidylcholine acyltransferase 3<i><i>; Tmem86b</i></i>: transmembrane protein 86b; <i><i>Tmem229B</i></i>: transmembrane protein 229b; <i>GPC</i>: glycerophosphocholine; <i>GPE:</i> glycerophosphoethanolamine.</p> |
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