Retrospective cohort analysis study design.
<div><p>Parkinson’s disease (PD) is an increasingly prevalent neurologic condition for which symptomatic, but not preventative, treatment is available. Drug repurposing is an innovate drug discovery method that uncovers existing therapeutics to treat or prevent conditions for which they...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1852020202967924736 |
|---|---|
| author | Maria P. Gorenflo (21395538) |
| author2 | Zhenxiang Gao (15596885) Pamela B. Davis (11588570) David Kaelber (11238188) Rong Xu (296325) |
| author2_role | author author author author |
| author_facet | Maria P. Gorenflo (21395538) Zhenxiang Gao (15596885) Pamela B. Davis (11588570) David Kaelber (11238188) Rong Xu (296325) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maria P. Gorenflo (21395538) Zhenxiang Gao (15596885) Pamela B. Davis (11588570) David Kaelber (11238188) Rong Xu (296325) |
| dc.date.none.fl_str_mv | 2025-05-20T17:55:17Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0323761.g002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Retrospective_cohort_analysis_study_design_/29113092 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Cell Biology Neuroscience Pharmacology Biotechnology Cancer Science Policy Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified uncovers existing therapeutics select potential drugs retrospective cohort analysis parkinson &# 8217 observational findings suggest biochemical processes implicated artificial intelligence prediction significantly reduced hazard amphetamine targets many 98 ), 0 hazard ratio 93 ), strongest candidate previous work prevent conditions main diagnosis inverse relationship incurable diseases drug repurposing dopaminergic synapses deidentified patients currently indicated confidence interval clinical corroboration amphetamine use 79 ). 6 years |
| dc.title.none.fl_str_mv | Retrospective cohort analysis study design. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <div><p>Parkinson’s disease (PD) is an increasingly prevalent neurologic condition for which symptomatic, but not preventative, treatment is available. Drug repurposing is an innovate drug discovery method that uncovers existing therapeutics to treat or prevent conditions for which they are not currently indicated, a method that could be applied to incurable diseases such as PD. A knowledge graph artificial intelligence prediction system was used to select potential drugs that could be used to treat or prevent PD, and amphetamine was identified as the strongest candidate. Retrospective cohort analysis on a large, electronic health record database of deidentified patients with attention deficit hyperactive disorder (the main diagnosis for which amphetamine is prescribed) revealed a significantly reduced hazard of developing PD in patients prescribed amphetamine versus patients not prescribed amphetamine at 2, 4, and 6 years: Hazard Ratio (95% Confidence Interval) = 0.59 (0.36, 0.98), 0.63 (0.42, 0.93), and 0.55 (0.38, 0.79). Pathway enrichment analysis confirmed that amphetamine targets many of the biochemical processes implicated in PD, such as dopaminergic synapses and neurodegeneration. Together, these observational findings suggest that therapeutic and legal amphetamine use may reduce the risk of developing PD, in contrast to previous work that found the inverse relationship in patients using amphetamine recreationally.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_02bb6cb22c162bdbdf06befc41c37cbf |
| identifier_str_mv | 10.1371/journal.pone.0323761.g002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29113092 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Retrospective cohort analysis study design.Maria P. Gorenflo (21395538)Zhenxiang Gao (15596885)Pamela B. Davis (11588570)David Kaelber (11238188)Rong Xu (296325)MedicineCell BiologyNeurosciencePharmacologyBiotechnologyCancerScience PolicyInfectious DiseasesEnvironmental Sciences not elsewhere classifiedBiological Sciences not elsewhere classifieduncovers existing therapeuticsselect potential drugsretrospective cohort analysisparkinson &# 8217observational findings suggestbiochemical processes implicatedartificial intelligence predictionsignificantly reduced hazardamphetamine targets many98 ), 0hazard ratio93 ),strongest candidateprevious workprevent conditionsmain diagnosisinverse relationshipincurable diseasesdrug repurposingdopaminergic synapsesdeidentified patientscurrently indicatedconfidence intervalclinical corroborationamphetamine use79 ).6 years<div><p>Parkinson’s disease (PD) is an increasingly prevalent neurologic condition for which symptomatic, but not preventative, treatment is available. Drug repurposing is an innovate drug discovery method that uncovers existing therapeutics to treat or prevent conditions for which they are not currently indicated, a method that could be applied to incurable diseases such as PD. A knowledge graph artificial intelligence prediction system was used to select potential drugs that could be used to treat or prevent PD, and amphetamine was identified as the strongest candidate. Retrospective cohort analysis on a large, electronic health record database of deidentified patients with attention deficit hyperactive disorder (the main diagnosis for which amphetamine is prescribed) revealed a significantly reduced hazard of developing PD in patients prescribed amphetamine versus patients not prescribed amphetamine at 2, 4, and 6 years: Hazard Ratio (95% Confidence Interval) = 0.59 (0.36, 0.98), 0.63 (0.42, 0.93), and 0.55 (0.38, 0.79). Pathway enrichment analysis confirmed that amphetamine targets many of the biochemical processes implicated in PD, such as dopaminergic synapses and neurodegeneration. Together, these observational findings suggest that therapeutic and legal amphetamine use may reduce the risk of developing PD, in contrast to previous work that found the inverse relationship in patients using amphetamine recreationally.</p></div>2025-05-20T17:55:17ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0323761.g002https://figshare.com/articles/figure/Retrospective_cohort_analysis_study_design_/29113092CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/291130922025-05-20T17:55:17Z |
| spellingShingle | Retrospective cohort analysis study design. Maria P. Gorenflo (21395538) Medicine Cell Biology Neuroscience Pharmacology Biotechnology Cancer Science Policy Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified uncovers existing therapeutics select potential drugs retrospective cohort analysis parkinson &# 8217 observational findings suggest biochemical processes implicated artificial intelligence prediction significantly reduced hazard amphetamine targets many 98 ), 0 hazard ratio 93 ), strongest candidate previous work prevent conditions main diagnosis inverse relationship incurable diseases drug repurposing dopaminergic synapses deidentified patients currently indicated confidence interval clinical corroboration amphetamine use 79 ). 6 years |
| status_str | publishedVersion |
| title | Retrospective cohort analysis study design. |
| title_full | Retrospective cohort analysis study design. |
| title_fullStr | Retrospective cohort analysis study design. |
| title_full_unstemmed | Retrospective cohort analysis study design. |
| title_short | Retrospective cohort analysis study design. |
| title_sort | Retrospective cohort analysis study design. |
| topic | Medicine Cell Biology Neuroscience Pharmacology Biotechnology Cancer Science Policy Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified uncovers existing therapeutics select potential drugs retrospective cohort analysis parkinson &# 8217 observational findings suggest biochemical processes implicated artificial intelligence prediction significantly reduced hazard amphetamine targets many 98 ), 0 hazard ratio 93 ), strongest candidate previous work prevent conditions main diagnosis inverse relationship incurable diseases drug repurposing dopaminergic synapses deidentified patients currently indicated confidence interval clinical corroboration amphetamine use 79 ). 6 years |