Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2

Cyclin-dependent kinase 2 (CDK2) plays an important role in cell cycle regulation and has emerged as a compelling target for the treatment of cancer, largely because of its potential to overcome the resistance associated with CDK4/6 inhibition. Efforts to develop CDK2 inhibitors have historically pr...

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Bibliographic Details
Main Author:	Philip N. Collier (1562239) (author)
Other Authors:	Xiaozhang Zheng (640341) (author), Melissa Ford (22096634) (author), Matthew Weiss (15007176) (author), Dapeng Chen (528941) (author), Kunhua Li (1576657) (author), Joseph D. Growney (796864) (author), Annan Yang (844721) (author), Murugappan Sathappa (22096637) (author), Susanne B. Breitkopf (202752) (author), Brad Enerson (18885393) (author), Tong Liang (667312) (author), Atanu Paul (5775491) (author), Rupa Sawant (22096640) (author), Lijing Su (348548) (author), Robert J. Aversa (1693627) (author), Charles Howarth (22096643) (author), Kirti Sharma (494137) (author), Juliet Williams (2219191) (author), Nicholas P. Kwiatkowski (2437774) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Marine Biology Cancer Infectious Diseases Chemical Sciences not elsewhere classified mice bearing ccne1 dependent kinase 2 cell cycle regulation target cdk isoforms develop cdk2 inhibitors clinical cdk2 inhibitor relevant cyclin e1 37 </ b compelling target resistance associated rb phosphorylation orally bioavailable important role greater specificity antitumor activity
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Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2

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