Clozapine suppressed MCF-7 cell growth via modulation of ROS.

<p>(A) MCF-7 cells were incubated with the indicated concentration of clozapine for up to 72 h and labeled with H<sub>2</sub>DCFDA (10 μM) to measure the total intracellular ROS content by flow cytometry. (B and C) Cells were treated with or without vitamin E (α-Tocopherol) to dete...

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Bibliographic Details
Main Author:	Ya-Chun Fan (21567690) (author)
Other Authors:	Shih-Chao Lin (3753646) (author), Po-Jung Lai (630383) (author), Pei-Chun Lai (10132949) (author), Germain Maurus (21567693) (author), Shiow-Yi Chen (160980) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Molecular Biology Physiology Pharmacology Biotechnology Immunology Developmental Biology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified western blotting analyses g1 phase arrest assess cell proliferation reduces cell viability induced cell death breast cancer cells term antipsychotic treatment ros ), apoptosis clozapine induces apoptosis reduces ros induced apoptosis antipsychotic drugs induced cytotoxicity similar ros ros plays ros generation induces autophagy used clonogenic upregulating p21 tumor effects therapeutic agent study investigates study demonstrates results show psychotic disorders psychiatric medication previous studies mtt assays flow cytometry findings suggest combining clozapine clozapine suppresses central role 231 cells
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Clozapine suppressed MCF-7 cell growth via modulation of ROS.

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