Estimated dominant, periodic-optima fitness surface for a dinucleotide microsatellite in the first intron of gene <i>COL1A2</i>.

Estimated dominant, periodic-optima fitness surface for a dinucleotide microsatellite in the first intron of gene <i>COL1A2</i>.

<p>Most genotypes contain a 20x or 25x allele in accordance with the estimated <i>α</i> = 5 in a periodic optimum model. The most prominent exceptions to this pattern are in the African YRI and LWK populations.</p>

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Bibliographic Details
Main Author:	Ryan J. Haasl (3259872) (author)
Other Authors:	Bret A. Payseur (7310231) (author)
Published:	2024
Subjects:	Genetics Evolutionary Biology Ecology Infectious Diseases Biological Sciences not elsewhere classified xlink "> advances scale analyses like random forests approach population genetic methods modulate gene expression dna sequencing technology selective dynamics navigated microsatellite fitness surfaces influence biological function selection remains uncharacterized characterizing selection assume single nucleotide variants harbor substantial variation fitness landscapes provide approximate bayesian computation fitness landscapes obvious function evolutionary dynamics affect fitness selection strengths natural selection wide scans variants mutate valuable visualization unprecedented scales two parameters specifically designed simple manner report suggests repetitive variants repetitive sequences optimal alleles mutate orders magnitude faster low rate intergenic loci identifying genes examining patterns eight populations easily simulated appreciable percentage 200 humans
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Summary:	<p>Most genotypes contain a 20x or 25x allele in accordance with the estimated <i>α</i> = 5 in a periodic optimum model. The most prominent exceptions to this pattern are in the African YRI and LWK populations.</p>

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