This figure is similar to Fig 3, except that we use arm-3 instead of arm-2.

This figure is similar to Fig 3, except that we use arm-3 instead of arm-2.

<p>The overall replication for arm-3 within the interval <i>i</i> ∈ [175, 350] is estimated at <i>p</i> ≲ 10<sup>3</sup>. Note that the SNP-overlap between arm-1 and arm-3 is only ∼ 50%.</p>

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Bibliographic Details
Main Author: Caroline C. McGrouther (5216153) (author)
Other Authors: Aaditya V. Rangan (14659986) (author), Arianna Di Florio (20636356) (author), Jeremy A. Elman (9602147) (author), Nicholas J. Schork (176346) (author), John Kelsoe (3437189) (author)
Published: 2025
Subjects:
Genetics
Neuroscience
Pharmacology
Biotechnology
Evolutionary Biology
Marine Biology
Mental Health
Infectious Diseases
Plant Biology
Biological Sciences not elsewhere classified
termed &# 8216
psychiatric genomics consortium
leverage recent advances
e ., biclusters
corrected biclustering algorithm
subgroup may represent
subgroup &# 8217
pgc containing 5781
various bd studies
bd subtype information
improve risk prediction
specific pattern highlighted
homogeneous genetic subgroup
relatively small subset
genetically homogeneous subtype
discovered without using
bicluster &# 8217
specific genetic pattern
correlated genetic risk
2524 bd cases
genetic heterogeneity delineating
disorder </ p
specific pattern
genetic subgroup
bd cases
genetic level
genetic data
pgc ).
9752 cases
bipolar disorder
xlink ">
successfully identified
subphenotypic data
subjects define
set aside
remaining data
related signal
prs ),
primary focus
particularly notable
one way
informed polygenic
gwas analyses
fully understood
first apply
expression across
eliminate noise
driven subgroups
challenging task
broad phenotype
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Summary:<p>The overall replication for arm-3 within the interval <i>i</i> ∈ [175, 350] is estimated at <i>p</i> ≲ 10<sup>3</sup>. Note that the SNP-overlap between arm-1 and arm-3 is only ∼ 50%.</p>

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