Model for the effects of L-2HG on chromocenters and centromeres.

<p>Upon binding of L-2HG, the target protein undergoes a conformational change. Some of the L-2HG-bound target protein translocates from the chromocenter to the centromere. The L-2HG-bound target induces condensation of nearby chromatin. This could occur either via protein-protein interactions...

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Main Author:	Nina Mayorek (241888) (author)
Other Authors:	Miriam Schlossberg (21696644) (author), Yousef Mansour (21696647) (author), Nir Pillar (5249612) (author), Ilan Stein (131429) (author), Fatima Mushasha (21696650) (author), Guy Baziza Paz (21696653) (author), Eleonora Medvedev (21696656) (author), Zakhariya Manevitch (21696659) (author), Julia Menzel (12879920) (author), Elina Aizenshtein (21696662) (author), Boris Sarvin (8232306) (author), Nikita Sarvin (21696665) (author), Erwin Goldberg (2868524) (author), Bryan A. Niedenberger (21696668) (author), Christopher B. Geyer (13840432) (author), Tomer Shlomi (22999) (author), Michael Klutstein (22329) (author), Eli Pikarsky (103960) (author)
Published:	2025
Subjects:	Cell Biology Genetics Molecular Biology Developmental Biology Biological Sciences not elsewhere classified spindle assembly checkpoint satellite rna expression sac ), suggesting producing functional spermatozoa histone methylation changes including chromocenter clustering 2hg ), yet regulates centromere condensation hydroxyglutarate regulates centromere chromocenter condensation centromere dysfunction vivo results synaptonemal complex localizing along heterochromatin conformation epigenetic modifications diplotene stages acute depletion
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Model for the effects of L-2HG on chromocenters and centromeres.

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