Model for the effects of L-2HG on chromocenters and centromeres.

Model for the effects of L-2HG on chromocenters and centromeres.

<p>Upon binding of L-2HG, the target protein undergoes a conformational change. Some of the L-2HG-bound target protein translocates from the chromocenter to the centromere. The L-2HG-bound target induces condensation of nearby chromatin. This could occur either via protein-protein interactions...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Nina Mayorek (241888) (author)
Awduron Eraill: Miriam Schlossberg (21696644) (author), Yousef Mansour (21696647) (author), Nir Pillar (5249612) (author), Ilan Stein (131429) (author), Fatima Mushasha (21696650) (author), Guy Baziza Paz (21696653) (author), Eleonora Medvedev (21696656) (author), Zakhariya Manevitch (21696659) (author), Julia Menzel (12879920) (author), Elina Aizenshtein (21696662) (author), Boris Sarvin (8232306) (author), Nikita Sarvin (21696665) (author), Erwin Goldberg (2868524) (author), Bryan A. Niedenberger (21696668) (author), Christopher B. Geyer (13840432) (author), Tomer Shlomi (22999) (author), Michael Klutstein (22329) (author), Eli Pikarsky (103960) (author)
Cyhoeddwyd: 2025
Pynciau:
Cell Biology
Genetics
Molecular Biology
Developmental Biology
Biological Sciences not elsewhere classified
spindle assembly checkpoint
satellite rna expression
sac ), suggesting
producing functional spermatozoa
histone methylation changes
including chromocenter clustering
2hg ), yet
regulates centromere condensation
hydroxyglutarate regulates centromere
chromocenter condensation
centromere dysfunction
vivo results
synaptonemal complex
localizing along
heterochromatin conformation
epigenetic modifications
diplotene stages
acute depletion
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