Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain

Activation of cytokine and growth factor receptors by ligands triggers crucial cellular responses in various physiological processes. However, our understanding of their structural basis remains incomplete due to the limited information on the active ligand–receptor complex structure. Their structur...

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Manylion Llyfryddiaeth
Prif Awdur:	Neval Yilmaz (1544557) (author)
Awduron Eraill:	Hiroki Tanino (22686882) (author), Shun Sakuraba (1368381) (author), Romain Amyot (9657017) (author), Holger Flechsig (213426) (author), Atsushi Matsumoto (593817) (author), Hidetoshi Kono (19475) (author), Leonardo Puppulin (11688279) (author), Mikihiro Shibata (2075461) (author), Hiroshi Aoyama (832169) (author), Tsuyoshi Inoue (559318) (author), Kunio Matsumoto (412408) (author), Katsuya Sakai (11688282) (author)
Cyhoeddwyd:	2025
Pynciau:	Biophysics Biochemistry Cell Biology Molecular Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified molecular dynamics simulations luciferase complementary assay hepatocyte growth factor growth factor receptors electron microscopy experiments chemically fixing prior also conducted split various physiological processes proximal domain activation proximal region sema domain ipt4 domain distal domain physiological hgf structural features resolution characterization protein level living cells limited information induced dimerization active complex
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Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
gan: Neval Yilmaz (1544557)
Cyhoeddwyd: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
gan: Neval Yilmaz (1544557)
Cyhoeddwyd: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
gan: Neval Yilmaz (1544557)
Cyhoeddwyd: (2025)

Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain
gan: Neval Yilmaz (1544557)
Cyhoeddwyd: (2025)

YajC co-expression does not alter the membrane localization or abundance of LdrA-FLAG.
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YajC recognition of LdrA requires both transmembrane and cytoplasmic domains.
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YajC Specifically Neutralizes Ldr Family Toxins.
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Overexpression of YajC is sufficient to alleviate LdrA-induced toxicity.
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Genetic Screen Identifies YajC as an LdrA-Neutralizing Factor.
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LdrA expression causes transient growth arrest and the FLAG tag does not affect its toxicity.
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Full, uncropped Western blot images corresponding to Fig 4A.
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Inducible overexpression of YajC-HA.
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Proximity labeling of the intermediary protein α-catenin between actin and β-catenin by STUPPIT.
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