Stepwise kinase activation of DDR1 and DDR2 (1 μM protein autophosphorylation assay).

<p><b>A.</b> Schematic diagrams showing the location of key JM4 and A-loop tyrosine residues in DDR1-K-WT and DDR2-K-WT constructs. Anti-pY JM4 #1 binds to pY569 in DDR1 and to pY521 in DDR2. Anti-pY JM4 #2 binds to pY586 in DDR1 and to pY538 in DDR2. Anti-pY A-loop antibody was ra...

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Auteur principal:	Ziteng Hao (22647882) (author)
Autres auteurs:	Birgit Leitinger (111622) (author)
Publié:	2025
Sujets:	Biophysics Biochemistry Cell Biology Molecular Biology Biotechnology Immunology Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified substrate phosphorylation rates mechanistic studies addressing key catalytic residues increased catalytic rates autosomal dominant manner atp binding affinity independent constitutive autophosphorylation missense variant bypasses y740c kinase constructs wt ddr2 kinase y740c kinase substituted variant missense mutations enhanced autophosphorylation ddr2 kinase ddr1 kinase y740c displayed wt ddr2 soluble wt xlink "> unphosphorylated ddr2 structural explanation skin fusion previously hypothesised mammalian cells length proteins keloid plaques function mechanism enzyme kinetics corneal vascularisation cinotti variants cinotti syndrome cause disease autoinhibitory constraints
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Stepwise kinase activation of DDR1 and DDR2 (1 μM protein autophosphorylation assay).

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