Targeted knockdown of AURKA induces growth inhibition, G2/M phase blockade, and apoptosis in NB cell line.

<p>(A) At MOI of 10, lentivirus transduction efficiency was estimated three days after infection (original magnification, ×200). (B) RT-qPCR of the expression of AURKA mRNA. (C, D) Western blotting of the expression of AURKA protein. (E, F) CCK8 cell proliferation experiment after interfering...

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Bibliographic Details
Main Author:	Jing Chu (15302053) (author)
Published:	2024
Subjects:	Cell Biology Genetics Molecular Biology Biotechnology Immunology Developmental Biology Cancer Hematology Infectious Diseases Virology specific lentivirus significantly shrna delivered via rank test showed protein kinase involved poor patient prognosis flow cytometry analysis bioinformatic analysis showed cell cycle regulation cell cycle arrest cell counting kit overall survival ). bp1 signaling pathway nb tumor microenvironment 77 nb samples cog risk group aurka gene encodes xlink "> neuroblastoma neuroblastoma </ p nb cell lines aurka knockdown inhibited cell cycle progression various immune cells level aurka expression xlink "> high xlink "> knockdown group cell proliferation immune cells free survival expression group aurka promoter aurka expression worse os type 2 subsequent experiments shorter os prognostic significance pathological type oncogenic role mycn status inss stage induced apoptosis independently prognostic human cancers geo databases enhanced infiltration cytokines lower bp1 phosphorylation biological function activated cd4
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Targeted knockdown of AURKA induces growth inhibition, G2/M phase blockade, and apoptosis in NB cell line.

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