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Bacterial Strains and Plasmids Used in This Study.

Bacterial Strains and Plasmids Used in This Study.

<p>Bacterial Strains and Plasmids Used in This Study.</p>

Guardat en:
Dades bibliogràfiques
Autor principal: Jianhua Liao (1393228) (author)
Altres autors: Jun Cheng (194158) (author), Baoqing Liu (1508821) (author), Yuzhi Shao (22683349) (author), Chunyan Meng (5993228) (author)
Publicat: 2025
Matèries:
Medicine
Microbiology
Cell Biology
Biotechnology
Evolutionary Biology
Ecology
Science Policy
Infectious Diseases
Virology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
therapeutic strategies aimed
novel therapeutic approaches
murine infection model
div >< p
defense mechanisms employed
conserved gene encoding
compromising membrane stability
affect biofilm formation
staphylococcus aureus </
reduced bacterial burden
improved host survival
maintaining mrsa ’
oxidative stress resistance
yqhg </
withstand host
reduced motility
oxidative stress
increasing resistance
stress adaptation
potential target
periplasmic protein
mrsa virulence
mrsa pathogenesis
key determinant
infected organs
increased sensitivity
imposed stresses
growing prevalence
findings highlight
existing antibiotics
critical need
attenuates virulence
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  • Spleen bacterial burden in mice infected with MRSA wild-type, ΔyqhG, and complemented strains.
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  • Kidney bacterial burden in mice infected with MRSA wild-type, Δ<i>yqhG</i>, and complemented strains.
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  • Quantification of cell-associated PSMs in wild-type, Δ<i>yqhG</i>, and complemented strains. Cell-associated PSMs were extracted from bacterial pellets using 6 M guanidine hydrochloride and quantified by reversed-phase HPLC. The Δ<i>yqhG</i> mutant exhibited a significant reduction in surface-bound PSMs compared with the wild-type strain, whereas complementation restored PSM levels to near wild-type values. Data represent mean ± s.e.m. from three independent experiments. Statistical analysis was performed using one-way ANOVA; *<i>P</i> < 0.05, ns, not significant.
    per: Jianhua Liao (1393228)
    Publicat: (2025)

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