Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology

Injectable, self-healing hydrogels with enhanced solubilization of hydrophobic drugs are urgently needed for antimicrobial intravaginal therapies. Here, we report the first hydrogel systems constructed of dynamic boronic esters cross-linking unimolecular micelles, which are a reservoir of antifungal...

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Bibliographic Details
Main Author:	Monika Gosecka (1607017) (author)
Other Authors:	Daria Jaworska-Krych (13759871) (author), Mateusz Gosecki (2910719) (author), Ewelina Wielgus (4455151) (author), Monika Marcinkowska (1792114) (author), Anna Janaszewska (2819074) (author), Barbara Klajnert-Maculewicz (2819077) (author)
Published:	2022
Subjects:	Biophysics Biochemistry Medicine Neuroscience Pharmacology Biotechnology Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified potential therapeutic platform linking unimolecular micelles gradually decreased due acrylamidephenylboronic acid ). 50 ° c 40 ° c broad antifungal properties urethane bonds enabled intermolecular hydrophobic interactions hbpgl significantly influences hbpgl core modification hbpgl core hydrophobized core via ester antimicrobial intravaginal therapies rheological properties including 30 mol %, hbpgl core hydrophobization hydrogels increased along drug encapsulation efficiency enhanced clotrimazole solubilization rheological properties 30 mol urethane derivatives neat hbpgl intravaginal delivery insoluble drug increased hydrophobicity hydrophobic drugs ester linkages enhanced solubilization encapsulation efficiency selective hydrophobization urgently needed thermal stability study demonstrates reduced dynamics ran </ proper selection phenyl units networks (< monohydroxyl units injectable hydrogel injectable behavior hyperbranched polyglycidol hydrogels resulted hydrogels constructed hydrogel constructed healing hydrogels healing ability gynecology injectable g </ elastic strength clotrimazole release clotrimazole increases building component also revealed acrylamide -< >< sub >- 2
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Self-Healable, Injectable Hydrogel with Enhanced Clotrimazole Solubilization as a Potential Therapeutic Platform for Gynecology

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