Time course of qMRI, functional, and strength measurs.
<p>Line plots showing the time course over the years since diagnosis. Each line represents an individual with LGMD-R9 and the same colors show the same participant. <b>A.</b> FF in the global thigh and global leg. <b>B.</b> FF in the most and least fat-replaced thigh an...
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| مؤلفون آخرون: | , , , , , , , , , , , |
| منشور في: |
2025
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| _version_ | 1852020983415701504 |
|---|---|
| author | Susanne S. Rauh (21192252) |
| author2 | Pierre-Yves Baudin (5562959) Tanya Stojkovic (445701) Simone Birnbaum (4780017) Valérie Decostre (115607) Rachida-Lydie Zanfongnon (21192255) Yves Fromes (2211283) Melissa T. Hooijmans (12009198) Gustav J. Strijkers (279024) Jean-Yves Hogrel (115609) Sophie Olivier (14817775) Benjamin Marty (737272) Harmen Reyngoudt (9349399) |
| author2_role | author author author author author author author author author author author author |
| author_facet | Susanne S. Rauh (21192252) Pierre-Yves Baudin (5562959) Tanya Stojkovic (445701) Simone Birnbaum (4780017) Valérie Decostre (115607) Rachida-Lydie Zanfongnon (21192255) Yves Fromes (2211283) Melissa T. Hooijmans (12009198) Gustav J. Strijkers (279024) Jean-Yves Hogrel (115609) Sophie Olivier (14817775) Benjamin Marty (737272) Harmen Reyngoudt (9349399) |
| author_role | author |
| dc.creator.none.fl_str_mv | Susanne S. Rauh (21192252) Pierre-Yves Baudin (5562959) Tanya Stojkovic (445701) Simone Birnbaum (4780017) Valérie Decostre (115607) Rachida-Lydie Zanfongnon (21192255) Yves Fromes (2211283) Melissa T. Hooijmans (12009198) Gustav J. Strijkers (279024) Jean-Yves Hogrel (115609) Sophie Olivier (14817775) Benjamin Marty (737272) Harmen Reyngoudt (9349399) |
| dc.date.none.fl_str_mv | 2025-04-28T17:40:21Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0321463.g005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Time_course_of_qMRI_functional_and_strength_measurs_/28885280 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biophysics Biochemistry Medicine Cell Biology Neuroscience Biotechnology Cancer Chemical Sciences not elsewhere classified qmri included assessment muscle fat fraction linear mixed models leg muscle mri h mr spectroscopy diffusion tensor imaging rare neuromuscular disease parametric quantitative mri bilateral quantitative mri 057 &# 8211 monitor disease progression evaluating disease progression 4s climb suggests 4s climb )), muscle strength tests lower limb muscles tug (&# 916 ff (&# 916 xlink "> limb water t2 parameters baseline water t1 1 </ sup disease progression &# 916 xlink "> water t2 water t1 4s climb quantitative thigh lower limbs strength parameters strength measures functional tests suitable biomarkers sensitive non reach significance overall tendency novel therapies longitudinal study invasive biomarkers findings suggest elevated ff effective biomarkers curative treatment 752 ). 05 ). |
| dc.title.none.fl_str_mv | Time course of qMRI, functional, and strength measurs. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Line plots showing the time course over the years since diagnosis. Each line represents an individual with LGMD-R9 and the same colors show the same participant. <b>A.</b> FF in the global thigh and global leg. <b>B.</b> FF in the most and least fat-replaced thigh and leg muscles (AM, VM, GM, TA). <b>C.</b> Functional measures NSAD and FVC. <b>D.</b> Strength tests for knee extension and ankle plantarflexion. The predicted strength is shown. AM, <i>adductor magnus</i>; VM, <i>vastus medialis</i>; GM, <i>gastrocnemius medialis</i>; TA, <i>tibialis anterior</i>; FF, fat fraction; FVC, forced vital capacity; NSAD, North Star Assessment for Limb-Girdle Type Muscular Dystrophies.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_0caab017e336f97ff63f632b2cbc9bcc |
| identifier_str_mv | 10.1371/journal.pone.0321463.g005 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/28885280 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Time course of qMRI, functional, and strength measurs.Susanne S. Rauh (21192252)Pierre-Yves Baudin (5562959)Tanya Stojkovic (445701)Simone Birnbaum (4780017)Valérie Decostre (115607)Rachida-Lydie Zanfongnon (21192255)Yves Fromes (2211283)Melissa T. Hooijmans (12009198)Gustav J. Strijkers (279024)Jean-Yves Hogrel (115609)Sophie Olivier (14817775)Benjamin Marty (737272)Harmen Reyngoudt (9349399)BiophysicsBiochemistryMedicineCell BiologyNeuroscienceBiotechnologyCancerChemical Sciences not elsewhere classifiedqmri included assessmentmuscle fat fractionlinear mixed modelsleg muscle mrih mr spectroscopydiffusion tensor imagingrare neuromuscular diseaseparametric quantitative mribilateral quantitative mri057 &# 8211monitor disease progressionevaluating disease progression4s climb suggests4s climb )),muscle strength testslower limb musclestug (&# 916ff (&# 916xlink "> limbwater t2 parametersbaseline water t11 </ supdisease progression&# 916xlink ">water t2water t14s climbquantitative thighlower limbsstrength parametersstrength measuresfunctional testssuitable biomarkerssensitive nonreach significanceoverall tendencynovel therapieslongitudinal studyinvasive biomarkersfindings suggestelevated ffeffective biomarkerscurative treatment752 ).05 ).<p>Line plots showing the time course over the years since diagnosis. Each line represents an individual with LGMD-R9 and the same colors show the same participant. <b>A.</b> FF in the global thigh and global leg. <b>B.</b> FF in the most and least fat-replaced thigh and leg muscles (AM, VM, GM, TA). <b>C.</b> Functional measures NSAD and FVC. <b>D.</b> Strength tests for knee extension and ankle plantarflexion. The predicted strength is shown. AM, <i>adductor magnus</i>; VM, <i>vastus medialis</i>; GM, <i>gastrocnemius medialis</i>; TA, <i>tibialis anterior</i>; FF, fat fraction; FVC, forced vital capacity; NSAD, North Star Assessment for Limb-Girdle Type Muscular Dystrophies.</p>2025-04-28T17:40:21ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0321463.g005https://figshare.com/articles/figure/Time_course_of_qMRI_functional_and_strength_measurs_/28885280CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/288852802025-04-28T17:40:21Z |
| spellingShingle | Time course of qMRI, functional, and strength measurs. Susanne S. Rauh (21192252) Biophysics Biochemistry Medicine Cell Biology Neuroscience Biotechnology Cancer Chemical Sciences not elsewhere classified qmri included assessment muscle fat fraction linear mixed models leg muscle mri h mr spectroscopy diffusion tensor imaging rare neuromuscular disease parametric quantitative mri bilateral quantitative mri 057 &# 8211 monitor disease progression evaluating disease progression 4s climb suggests 4s climb )), muscle strength tests lower limb muscles tug (&# 916 ff (&# 916 xlink "> limb water t2 parameters baseline water t1 1 </ sup disease progression &# 916 xlink "> water t2 water t1 4s climb quantitative thigh lower limbs strength parameters strength measures functional tests suitable biomarkers sensitive non reach significance overall tendency novel therapies longitudinal study invasive biomarkers findings suggest elevated ff effective biomarkers curative treatment 752 ). 05 ). |
| status_str | publishedVersion |
| title | Time course of qMRI, functional, and strength measurs. |
| title_full | Time course of qMRI, functional, and strength measurs. |
| title_fullStr | Time course of qMRI, functional, and strength measurs. |
| title_full_unstemmed | Time course of qMRI, functional, and strength measurs. |
| title_short | Time course of qMRI, functional, and strength measurs. |
| title_sort | Time course of qMRI, functional, and strength measurs. |
| topic | Biophysics Biochemistry Medicine Cell Biology Neuroscience Biotechnology Cancer Chemical Sciences not elsewhere classified qmri included assessment muscle fat fraction linear mixed models leg muscle mri h mr spectroscopy diffusion tensor imaging rare neuromuscular disease parametric quantitative mri bilateral quantitative mri 057 &# 8211 monitor disease progression evaluating disease progression 4s climb suggests 4s climb )), muscle strength tests lower limb muscles tug (&# 916 ff (&# 916 xlink "> limb water t2 parameters baseline water t1 1 </ sup disease progression &# 916 xlink "> water t2 water t1 4s climb quantitative thigh lower limbs strength parameters strength measures functional tests suitable biomarkers sensitive non reach significance overall tendency novel therapies longitudinal study invasive biomarkers findings suggest elevated ff effective biomarkers curative treatment 752 ). 05 ). |