Identification of TesA as the periplasmic partner of YbbAP.

Identification of TesA as the periplasmic partner of YbbAP.

<p><b>(A)</b> Pairwise <i><i>in silico</i></i> co-folding of YbbP with all sec/tat secreted proteins from <i><i>Escherichia coli</i></i>. Each co-fold attempt is represented on the 2D plot by their pDockQ score and Molprobity clash sc...

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Bibliografiske detaljer
Hovedforfatter:	Martin B. L. McAndrew (22683641) (author)
Andre forfattere:	Jonathan Cook (3435386) (author), Amy Gill (14910614) (author), Kavya Sahoo (22683644) (author), Clare Thomas (7943747) (author), Phillip J. Stansfeld (1267617) (author), Allister Crow (263807) (author)
Udgivet:	2025
Fag:	Biophysics Biochemistry Microbiology Cell Biology Molecular Biology Biotechnology Developmental Biology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified tolc efflux pump multifunctional hydrolytic enzyme extracts hydrophobic compounds extracting hydrophobic molecules capture implied long bacterial cell envelope active site residues lipid hydrolase complex escherichia coli </ data suggests ybbap abc superfamily ’ div >< p coli </ abc superfamily thioester substrates tesa complex structural characterization remarkable diversity new function mechanotransmission mechanism inner membrane extensively characterized experimentally confirm complete ybbap >, three
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Lignende værker

Structures of YbbAP and the YbbAP-TesA complex.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Esterase and thioesterase activity of YbbAP-TesA.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Evidence for a mechanotransmission mechanism in YbbAP-TesA.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Evidence for a mechanotransmission mechanism in YbbAP-TesA.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Comparison of YbbAP-TesA and BceAB-BceS.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Roving camera tour of the cryoEM map underpinning the YbbAP-TesA structure.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Image processing workflow for the AMP-PNP-bound YbbAP-TesA complex cryo-EM reconstruction.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Molecular dynamics simulations of YbbAP suggest the periplasmic-side pocket is a lipid-binding site.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

LysoPG trajectory in atomistic simulation of YbbAP.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Coevolving residue pairs mapped to the YbbP-TesA interface.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Lipid residency distributions during coarse-grained simulations of YbbAP.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Image processing workflow for the apo YbbAP cryo-EM reconstruction.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Image processing workflow for the AMP-PNP-bound YbbAP cryo-EM reconstruction.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Atomistic molecular dynamics simulation showing partial extraction of a lipid from the bilayer by YbbAP.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Root-mean-square fluctuation (RMSF) and Root-mean-square deviation (RMSD) calculations for atomistic simulations of YbbAP.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Amino acid sequence conservation in TesA.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Mutational analysis of the TesA active site and in vivo esterase activity.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Nitrocefin and p-nitrophenyl butyrate hydrolysis assays for Pseudomonas <i>aeruginosa</i> TesA.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Biological functions of the four Type VII ABC transporters in <i>Escherichia coli.</i>
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Contact propensity data underpinning S9 Fig in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Molecular dynamics data underpinning S8 Fig in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Enzymatic data underpinning S5C Fig in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Enzymatic data underpinning S5B Fig in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Raw SDS-PAGE gel underpinning S5A Fig in PowerPoint format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Molecular dynamics data underpinning Fig 6C in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

In vivo ester hydrolysis data underpinning Fig 5A in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Ester hydrolysis data underpinning Fig 4E in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Nitrocefin hydrolysis data underpinning Fig 4D in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Acetyl CoA hydrolysis data underpinning Fig 4C in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Comparative rates of hydrolysis underpinning Fig 4B in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

p-Nitrophenyl butyrate hydrolysis data underpinning Fig 4A in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Raw SDS-PAGE gels underpinning Fig 1D in PowerPoint format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Coevolution data underpinning histogram in Fig 1C in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

<i>In silico</i> pull-down data underpinning Fig 1A in Excel format.
af: Martin B. L. McAndrew (22683641)
Udgivet: (2025)

Suggested mechanism of p7 dimerization at the ER membrane surface, based on results from this study.
af: Oluwatoyin Campbell (14392137)
Udgivet: (2025)

Correlation of protein and lipid motions in the <i>Surface</i> model.
af: Oluwatoyin Campbell (14392137)
Udgivet: (2025)

Protein-lipid interactions in the <i>Surface</i> model.
af: Oluwatoyin Campbell (14392137)
Udgivet: (2025)

Energetics of protein interactions.
af: Oluwatoyin Campbell (14392137)
Udgivet: (2025)

Residue contact comparison with reference dimer structure.
af: Oluwatoyin Campbell (14392137)
Udgivet: (2025)

Protein conformational dynamics induced by presence of a lipid membrane.
af: Oluwatoyin Campbell (14392137)
Udgivet: (2025)

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