Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells (
<p>Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circl...
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| _version_ | 1849927626372677632 |
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| author | Tine Struyve (22683295) |
| author2 | Marion Pardons (6407921) Jozefien De Clercq (17737815) Liesbet Termote (22683298) Laurens Lambrechts (10532207) Ytse Noppe (22683301) Mathias Lichterfeld (57148) Sofie Rutsaert (10667718) Linos Vandekerckhove (105574) |
| author2_role | author author author author author author author author |
| author_facet | Tine Struyve (22683295) Marion Pardons (6407921) Jozefien De Clercq (17737815) Liesbet Termote (22683298) Laurens Lambrechts (10532207) Ytse Noppe (22683301) Mathias Lichterfeld (57148) Sofie Rutsaert (10667718) Linos Vandekerckhove (105574) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tine Struyve (22683295) Marion Pardons (6407921) Jozefien De Clercq (17737815) Liesbet Termote (22683298) Laurens Lambrechts (10532207) Ytse Noppe (22683301) Mathias Lichterfeld (57148) Sofie Rutsaert (10667718) Linos Vandekerckhove (105574) |
| dc.date.none.fl_str_mv | 2025-11-25T18:40:43Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.ppat.1013702.g004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Frequencies_and_phenotypes_of_p24_cells_following_PMA_Tat_LNP_stimulation_A-D_CD4_T_cells_from_Acute_UD_Acute_UD_5_Chronic_UD_and_Chronic_UD_x_individuals_were_stimulated_for_24h_with_PMA_Tat_LNP_A_Frequencies_of_p24_cells_in_CD4_T_cells_Me/30714922 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Medicine Neuroscience Biotechnology Evolutionary Biology Ecology Cancer Infectious Diseases Plant Biology Virology Computational Biology phorbol myristate acetate integration selection mechanisms xlink "> persistence small reservoir sizes treatment initiation timing clonal expansion contributes art ), irrespective individuals treated shortly reservoir persistence early reservoir persistence clonal expansion started treatment pma ), art initiation viral reservoir treated individuals inducible reservoir individuals treated 1 reservoir suggesting post proviruses integrated progressively enriched one year major barrier longitudinal analysis heterochromatin regions five years chronic cohorts cell compartment antiretroviral therapy already detected |
| dc.title.none.fl_str_mv | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells ( |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells (</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_0f64289a65ffbcc59e861399a47f1cd0 |
| identifier_str_mv | 10.1371/journal.ppat.1013702.g004 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30714922 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells (Tine Struyve (22683295)Marion Pardons (6407921)Jozefien De Clercq (17737815)Liesbet Termote (22683298)Laurens Lambrechts (10532207)Ytse Noppe (22683301)Mathias Lichterfeld (57148)Sofie Rutsaert (10667718)Linos Vandekerckhove (105574)BiochemistryMedicineNeuroscienceBiotechnologyEvolutionary BiologyEcologyCancerInfectious DiseasesPlant BiologyVirologyComputational Biologyphorbol myristate acetateintegration selection mechanismsxlink "> persistencesmall reservoir sizestreatment initiation timingclonal expansion contributesart ), irrespectiveindividuals treated shortlyreservoir persistence earlyreservoir persistenceclonal expansionstarted treatmentpma ),art initiationviral reservoirtreated individualsinducible reservoirindividuals treated1 reservoirsuggesting postproviruses integratedprogressively enrichedone yearmajor barrierlongitudinal analysisheterochromatin regionsfive yearschronic cohortscell compartmentantiretroviral therapyalready detected<p>Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells (</p>2025-11-25T18:40:43ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.ppat.1013702.g004https://figshare.com/articles/figure/Frequencies_and_phenotypes_of_p24_cells_following_PMA_Tat_LNP_stimulation_A-D_CD4_T_cells_from_Acute_UD_Acute_UD_5_Chronic_UD_and_Chronic_UD_x_individuals_were_stimulated_for_24h_with_PMA_Tat_LNP_A_Frequencies_of_p24_cells_in_CD4_T_cells_Me/30714922CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307149222025-11-25T18:40:43Z |
| spellingShingle | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells ( Tine Struyve (22683295) Biochemistry Medicine Neuroscience Biotechnology Evolutionary Biology Ecology Cancer Infectious Diseases Plant Biology Virology Computational Biology phorbol myristate acetate integration selection mechanisms xlink "> persistence small reservoir sizes treatment initiation timing clonal expansion contributes art ), irrespective individuals treated shortly reservoir persistence early reservoir persistence clonal expansion started treatment pma ), art initiation viral reservoir treated individuals inducible reservoir individuals treated 1 reservoir suggesting post proviruses integrated progressively enriched one year major barrier longitudinal analysis heterochromatin regions five years chronic cohorts cell compartment antiretroviral therapy already detected |
| status_str | publishedVersion |
| title | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells ( |
| title_full | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells ( |
| title_fullStr | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells ( |
| title_full_unstemmed | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells ( |
| title_short | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells ( |
| title_sort | Frequencies and phenotypes of p24 + cells following PMA/Tat_LNP stimulation. (A-D) CD4 T cells from Acute UD, Acute UD + 5, Chronic UD and Chronic UD + x individuals were stimulated for 24h with PMA/Tat_LNP (A) Frequencies of p24 + cells in CD4 T cells. Median values are plotted. Open circles represent limit of detection (LOD). (B) Percentages of HIV-infected cells expressing the p24 protein following stimulation. Median values are plotted. Participants with an LOD frequency of p24 + cells in CD4 T cells or unreportable/unavailable total HIV DNA quantification were not included in this analysis. (C) Frequencies of cells with a given phenotype (TN, TCM/TTM, TEM, TTd) in p24+ and p24- fractions. Participants with a minimal number of 4 p24 + cells are represented. Grey bars depict median values. (D) Proportions of all p24 + cells with a given phenotype (TN, TCM/TTM, TEM, TTd). p24 + cells ( |
| topic | Biochemistry Medicine Neuroscience Biotechnology Evolutionary Biology Ecology Cancer Infectious Diseases Plant Biology Virology Computational Biology phorbol myristate acetate integration selection mechanisms xlink "> persistence small reservoir sizes treatment initiation timing clonal expansion contributes art ), irrespective individuals treated shortly reservoir persistence early reservoir persistence clonal expansion started treatment pma ), art initiation viral reservoir treated individuals inducible reservoir individuals treated 1 reservoir suggesting post proviruses integrated progressively enriched one year major barrier longitudinal analysis heterochromatin regions five years chronic cohorts cell compartment antiretroviral therapy already detected |