SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts.
<p>Random subsampling is used to calculate intra-category variability and the error bars indicate the standard deviation of one-half.</p> <p>(TIFF)</p>
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2025
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| _version_ | 1852015571112034304 |
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| author | Kashyap Chhatbar (9515350) |
| author2 | Adrian Bird (84938) Guido Sanguinetti (343362) |
| author2_role | author author |
| author_facet | Kashyap Chhatbar (9515350) Adrian Bird (84938) Guido Sanguinetti (343362) |
| author_role | author |
| dc.creator.none.fl_str_mv | Kashyap Chhatbar (9515350) Adrian Bird (84938) Guido Sanguinetti (343362) |
| dc.date.none.fl_str_mv | 2025-10-23T17:46:58Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pgen.1011908.s005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/SHAP_values_for_chromatin-associated_proteins_profiled_in_Hughes_et_al_21_and_Wang_et_al_22_Absolute_mean_DeepSHAP_values_computed_for_A_direct_targets_INTS11_degron_B_direct_targets_SET1A_degron_C_direct_targets_ZC3H4_degron_D_direct_targe/30432081 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Microbiology Cell Biology Genetics Molecular Biology Marine Biology Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified suggesting crosstalk mediated shapley additive explanations predict rna pol mechanistically remains challenging infer functional relevance dependent regulatory networks integrating predictive modelling insights using data based perturbation experiments associated protein profiles unravel complex context unperturbed data perturbation even modelling transcription associated proteins restrictor complex integrator complex compass complex unperturbed conditions transcriptional regulation transcriptional changes influencing transcription ii occupancy genes ranked gene bodies findings highlight experimental validation cooperative roles analysis reveals also captures |
| dc.title.none.fl_str_mv | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Random subsampling is used to calculate intra-category variability and the error bars indicate the standard deviation of one-half.</p> <p>(TIFF)</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_0fbccb41c396020e987911087bb7deb0 |
| identifier_str_mv | 10.1371/journal.pgen.1011908.s005 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30432081 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts.Kashyap Chhatbar (9515350)Adrian Bird (84938)Guido Sanguinetti (343362)BiochemistryMicrobiologyCell BiologyGeneticsMolecular BiologyMarine BiologyPlant BiologyBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedsuggesting crosstalk mediatedshapley additive explanationspredict rna polmechanistically remains challenginginfer functional relevancedependent regulatory networksintegrating predictive modellinginsights using databased perturbation experimentsassociated protein profilesunravel complex contextunperturbed dataperturbation evenmodelling transcriptionassociated proteinsrestrictor complexintegrator complexcompass complexunperturbed conditionstranscriptional regulationtranscriptional changesinfluencing transcriptionii occupancygenes rankedgene bodiesfindings highlightexperimental validationcooperative rolesanalysis revealsalso captures<p>Random subsampling is used to calculate intra-category variability and the error bars indicate the standard deviation of one-half.</p> <p>(TIFF)</p>2025-10-23T17:46:58ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pgen.1011908.s005https://figshare.com/articles/figure/SHAP_values_for_chromatin-associated_proteins_profiled_in_Hughes_et_al_21_and_Wang_et_al_22_Absolute_mean_DeepSHAP_values_computed_for_A_direct_targets_INTS11_degron_B_direct_targets_SET1A_degron_C_direct_targets_ZC3H4_degron_D_direct_targe/30432081CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304320812025-10-23T17:46:58Z |
| spellingShingle | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts. Kashyap Chhatbar (9515350) Biochemistry Microbiology Cell Biology Genetics Molecular Biology Marine Biology Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified suggesting crosstalk mediated shapley additive explanations predict rna pol mechanistically remains challenging infer functional relevance dependent regulatory networks integrating predictive modelling insights using data based perturbation experiments associated protein profiles unravel complex context unperturbed data perturbation even modelling transcription associated proteins restrictor complex integrator complex compass complex unperturbed conditions transcriptional regulation transcriptional changes influencing transcription ii occupancy genes ranked gene bodies findings highlight experimental validation cooperative roles analysis reveals also captures |
| status_str | publishedVersion |
| title | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts. |
| title_full | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts. |
| title_fullStr | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts. |
| title_full_unstemmed | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts. |
| title_short | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts. |
| title_sort | SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts. |
| topic | Biochemistry Microbiology Cell Biology Genetics Molecular Biology Marine Biology Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified suggesting crosstalk mediated shapley additive explanations predict rna pol mechanistically remains challenging infer functional relevance dependent regulatory networks integrating predictive modelling insights using data based perturbation experiments associated protein profiles unravel complex context unperturbed data perturbation even modelling transcription associated proteins restrictor complex integrator complex compass complex unperturbed conditions transcriptional regulation transcriptional changes influencing transcription ii occupancy genes ranked gene bodies findings highlight experimental validation cooperative roles analysis reveals also captures |