SHAP values for chromatin-associated proteins profiled in Hughes et al. [21] and Wang et al. [22] Absolute mean DeepSHAP values computed for (A) direct targets (INTS11 degron) (B) direct targets (SET1A degron) (C) direct targets (ZC3H4 degron) (D) direct targets (SET1A+ZC3H4 degron) and random genes at promoter and gene body contexts.

<p>Random subsampling is used to calculate intra-category variability and the error bars indicate the standard deviation of one-half.</p> <p>(TIFF)</p>

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Bibliographic Details
Main Author:	Kashyap Chhatbar (9515350) (author)
Other Authors:	Adrian Bird (84938) (author), Guido Sanguinetti (343362) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Marine Biology Plant Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified suggesting crosstalk mediated shapley additive explanations predict rna pol mechanistically remains challenging infer functional relevance dependent regulatory networks integrating predictive modelling insights using data based perturbation experiments associated protein profiles unravel complex context unperturbed data perturbation even modelling transcription associated proteins restrictor complex integrator complex compass complex unperturbed conditions transcriptional regulation transcriptional changes influencing transcription ii occupancy genes ranked gene bodies findings highlight experimental validation cooperative roles analysis reveals also captures
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