Spatial stratification of each spatial domain cluster elucidating endothelial cell invasion into the tumor.

Spatial stratification of each spatial domain cluster elucidating endothelial cell invasion into the tumor.

<p>(A) Spatial distributions of stratified spatial domain clusters into (−30, 0], (0, +30], and (+30, +60] sections. (B) Violin plots showing the endothelial cell marker gene expressions (<i>PECAM1</i>, <i>VWF</i>, and <i>CD93</i>) for each cluster in the (−...

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Main Author: Shunsuke A. Sakai (13789939) (author)
Other Authors: Ryosuke Nomura (20746334) (author), Satoi Nagasawa (697597) (author), SungGi Chi (18386476) (author), Ayako Suzuki (380214) (author), Yutaka Suzuki (1379) (author), Mitsuho Imai (8906186) (author), Yoshiaki Nakamura (3981626) (author), Takayuki Yoshino (616028) (author), Shumpei Ishikawa (154679) (author), Katsuya Tsuchihara (392821) (author), Shun-Ichiro Kageyama (2986365) (author), Riu Yamashita (1612) (author)
Published: 2025
Subjects:
Biotechnology
Developmental Biology
Cancer
Plant Biology
Virology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Information Systems not elsewhere classified
potentially reflect histology
detect histological morphology
observed tumor vascularization
metastatic colorectal cancer
xlink "> single
skny ): extending
identify microenvironment features
detects spatial domains
tumor microenvironment
cancer progression
breast cancer
spatial extension
spatial domains
spatial domain
trajectory estimation
surrounding area
stage progression
skny facilitates
skny algorithm
skny ),
divided based
based toolkit
14 patients
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Description
Summary:<p>(A) Spatial distributions of stratified spatial domain clusters into (−30, 0], (0, +30], and (+30, +60] sections. (B) Violin plots showing the endothelial cell marker gene expressions (<i>PECAM1</i>, <i>VWF</i>, and <i>CD93</i>) for each cluster in the (−30, 0], (0, +30], and (+30, +60] sections. The x-axes indicate cluster numbers, and the y-axes indicate scaled gene expression levels. The annotated values are the <i>P</i> values of the significance test. (C) Representative images of DAPI with epithelial cell markers (<i>CDH1</i> and <i>EPCAM</i>) and endothelial cell marker (<i>CD93</i>, <i>PECAM1</i>, and <i>VWF</i>) expression for four ROIs.</p>

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