New function of <i>S. coelicolor</i> NagA and an updated amino sugar metabolic pathway.

New function of <i>S. coelicolor</i> NagA and an updated amino sugar metabolic pathway.

<p>Extracted ion chromatograms for compound <b>1</b> (<i>m</i>/<i>z</i> 282.0387, shown in black lines) and compound <b>2</b>/<b>3</b> (<i>m</i>/<i>z</i> 240.0280, shown in red lines) in the enzymatic reaction...

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Autore principale:	Chao Li (145513) (author)
Altri autori:	Mia Urem (22683580) (author), Ioli Kotsogianni (9930187) (author), Josephine Lau (20442343) (author), Chao Du (288036) (author), Somayah S. Elsayed (9192571) (author), Nathaniel I. Martin (847378) (author), Iain W. McNae (840777) (author), Patrick Voskamp (2311429) (author), Christoph Mayer (57204) (author), Sébastien Rigali (724082) (author), Navraj Pannu (10163763) (author), Jan Pieter Abrahams (1429531) (author), Lennart Schada von Borzyskowski (22683583) (author), Gilles P. van Wezel (7838948) (author)
Pubblicazione:	2025
Soggetti:	Biochemistry Microbiology Ecology Developmental Biology Inorganic Chemistry Biological Sciences not elsewhere classified controls nutrient signaling also revealed 6 highlighted key residues glcnac sensing requires toxicity pathway dependent 6p deacetylase naga novel glcnac 6 key role substrate glcnac novel enzyme work uncovers wall leads unprecedented reaction substrate mycelium structural analogue streptomycetaceae </ streptomyces </ revolves around promiscuous activity nature ’ n </ multicellular lifestyle metabolic checkpoint medicine makers lytic dismantling landmark event hyphal cell highly conserved growth media function analysis clinical antibiotics central metabolism catalytic inhibitor antibiotic production active site >- acetylglucosamine 6p dehydratase
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