Mutation rate curves used to simulate dinucleotide and trinucleotide microsatellites.

<p>Alleles of greater size are more mutable. Each microsatellite motif size is represented by five curves to capture uncertainty and variability in mutation rate. The most reliable curves are those for dinucleotides and tetranucleotides, where the middle curve of each set was empirically estim...

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Bibliographic Details
Main Author:	Ryan J. Haasl (3259872) (author)
Other Authors:	Bret A. Payseur (7310231) (author)
Published:	2024
Subjects:	Genetics Evolutionary Biology Ecology Infectious Diseases Biological Sciences not elsewhere classified xlink "> advances scale analyses like random forests approach population genetic methods modulate gene expression dna sequencing technology selective dynamics navigated microsatellite fitness surfaces influence biological function selection remains uncharacterized characterizing selection assume single nucleotide variants harbor substantial variation fitness landscapes provide approximate bayesian computation fitness landscapes obvious function evolutionary dynamics affect fitness selection strengths natural selection wide scans variants mutate valuable visualization unprecedented scales two parameters specifically designed simple manner report suggests repetitive variants repetitive sequences optimal alleles mutate orders magnitude faster low rate intergenic loci identifying genes examining patterns eight populations easily simulated appreciable percentage 200 humans
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Mutation rate curves used to simulate dinucleotide and trinucleotide microsatellites.

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