Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
<p>Supplementary Figure 4. The effect of ATF2 siRNA on gene expression and PT340 FST induced chemoresistance. A. Schematic detailing the transwell experiments. CellTrace Violet cells were sorted for rapidly dividing (Dim) or quiescent cells (Bright) which were then plated in transwell chambers...
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| _version_ | 1849927633374019584 |
|---|---|
| author | Alexander J. Cole (14971167) |
| author2 | Santiago Panesso-Gómez (14971170) Jaynish S. Shah (14971173) Tonge Ebai (14971176) Qi Jiang (14971179) Ece Gumusoglu-Acar (14971182) Maya G. Bello (14971185) Anda Vlad (14960061) Francesmary Modugno (14960046) Robert P. Edwards (14971188) Ronald J. Buckanovich (14971191) |
| author2_role | author author author author author author author author author author |
| author_facet | Alexander J. Cole (14971167) Santiago Panesso-Gómez (14971170) Jaynish S. Shah (14971173) Tonge Ebai (14971176) Qi Jiang (14971179) Ece Gumusoglu-Acar (14971182) Maya G. Bello (14971185) Anda Vlad (14960061) Francesmary Modugno (14960046) Robert P. Edwards (14971188) Ronald J. Buckanovich (14971191) |
| author_role | author |
| dc.creator.none.fl_str_mv | Alexander J. Cole (14971167) Santiago Panesso-Gómez (14971170) Jaynish S. Shah (14971173) Tonge Ebai (14971176) Qi Jiang (14971179) Ece Gumusoglu-Acar (14971182) Maya G. Bello (14971185) Anda Vlad (14960061) Francesmary Modugno (14960046) Robert P. Edwards (14971188) Ronald J. Buckanovich (14971191) |
| dc.date.none.fl_str_mv | 2025-11-25T13:04:26Z |
| dc.identifier.none.fl_str_mv | 10.1158/1078-0432.30707168 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_S4_from_Quiescent_Ovarian_Cancer_Cells_Secrete_Follistatin_to_Induce_Chemotherapy_Resistance_in_Surrounding_Cells_in_Response_to_Chemotherapy/30707168 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Tumor Biology Molecular and Cellular Biology Therapeutic Research and Development Cell Signaling Autocrine-paracrine signaling Drug Resistance Novel mechanisms Genitourinary Cancers Translational Research Tumor Heterogeneity |
| dc.title.none.fl_str_mv | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Supplementary Figure 4. The effect of ATF2 siRNA on gene expression and PT340 FST induced chemoresistance. A. Schematic detailing the transwell experiments. CellTrace Violet cells were sorted for rapidly dividing (Dim) or quiescent cells (Bright) which were then plated in transwell chambers either as Dim:Dim or Bright:Dim. Cells were untreated or treated with taxol alone or in combination with IgG or anti-FST antibody. Cell counts were performed on the dim cells and data was expressed as fold chnage. B. Relative ATF2 gene expression of PT412 and PT340 treated with scrambled siRNA or two independent ATF2 siRNAs (ATF2 siRNA #1 and #2). C. Viable cell number of PT340 cells treated with control scrambled siRNA or knocked down with ATF2 siRNA and treated with cisplatin +/- FST. *P<0.05, ns = not significant.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_119cd245656ed10c5bd108d6078bb808 |
| identifier_str_mv | 10.1158/1078-0432.30707168 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30707168 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to ChemotherapyAlexander J. Cole (14971167)Santiago Panesso-Gómez (14971170)Jaynish S. Shah (14971173)Tonge Ebai (14971176)Qi Jiang (14971179)Ece Gumusoglu-Acar (14971182)Maya G. Bello (14971185)Anda Vlad (14960061)Francesmary Modugno (14960046)Robert P. Edwards (14971188)Ronald J. Buckanovich (14971191)CancerTumor BiologyMolecular and Cellular BiologyTherapeutic Research and DevelopmentCell SignalingAutocrine-paracrine signalingDrug ResistanceNovel mechanismsGenitourinary CancersTranslational ResearchTumor Heterogeneity<p>Supplementary Figure 4. The effect of ATF2 siRNA on gene expression and PT340 FST induced chemoresistance. A. Schematic detailing the transwell experiments. CellTrace Violet cells were sorted for rapidly dividing (Dim) or quiescent cells (Bright) which were then plated in transwell chambers either as Dim:Dim or Bright:Dim. Cells were untreated or treated with taxol alone or in combination with IgG or anti-FST antibody. Cell counts were performed on the dim cells and data was expressed as fold chnage. B. Relative ATF2 gene expression of PT412 and PT340 treated with scrambled siRNA or two independent ATF2 siRNAs (ATF2 siRNA #1 and #2). C. Viable cell number of PT340 cells treated with control scrambled siRNA or knocked down with ATF2 siRNA and treated with cisplatin +/- FST. *P<0.05, ns = not significant.</p>2025-11-25T13:04:26ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/1078-0432.30707168https://figshare.com/articles/figure/Figure_S4_from_Quiescent_Ovarian_Cancer_Cells_Secrete_Follistatin_to_Induce_Chemotherapy_Resistance_in_Surrounding_Cells_in_Response_to_Chemotherapy/30707168CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307071682025-11-25T13:04:26Z |
| spellingShingle | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy Alexander J. Cole (14971167) Cancer Tumor Biology Molecular and Cellular Biology Therapeutic Research and Development Cell Signaling Autocrine-paracrine signaling Drug Resistance Novel mechanisms Genitourinary Cancers Translational Research Tumor Heterogeneity |
| status_str | publishedVersion |
| title | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy |
| title_full | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy |
| title_fullStr | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy |
| title_full_unstemmed | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy |
| title_short | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy |
| title_sort | Figure S4 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy |
| topic | Cancer Tumor Biology Molecular and Cellular Biology Therapeutic Research and Development Cell Signaling Autocrine-paracrine signaling Drug Resistance Novel mechanisms Genitourinary Cancers Translational Research Tumor Heterogeneity |