Expression of <i>SHH</i> in the FEZ after RCAS-virus infection to induce overexpression and knockdown of <i>PBX1</i> and <i>PBX3.</i>

Expression of <i>SHH</i> in the FEZ after RCAS-virus infection to induce overexpression and knockdown of <i>PBX1</i> and <i>PBX3.</i>

<p>RCAS-<i>PBX1</i>, RCAS-<i>PBX3</i>, RCAS-mir<i>PBX1</i>, RCAS-mir<i>PBX3</i>, and RCAS-AP/RCAS-mirLacZ control viruses were used to infect embryos at HH10<i>.</i> After 72 hours (HH22), the resulting expression patterns of <i>...

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Bibliographic Details
Main Author:	Chan Hee Mok (11247669) (author)
Other Authors:	Diane Hu (332774) (author), Marta Losa (9767709) (author), Maurizio Risolino (404733) (author), Licia Selleri (3589550) (author), Ralph S. Marcucio (8939357) (author)
Published:	2025
Subjects:	Cell Biology Genetics Molecular Biology Developmental Biology Biological Sciences not elsewhere classified using rcas viruses profiling epigenomic landscapes present study identifies omics approaches uncovered frontonasal ectodermal zone early developmental stages div >< p cell leukemia homeobox luciferase reporter assays chick face beginning assess direct interactions 400 bp pbx1 3 either directly element upregulates transcription specific interactions reporter constructs chick embryos repressing transcription downregulates transcription vitro </ stage 10 sonic hedgehog research establishes regulatory element performed atac pbxs act pbx1 </ ovo </ opposite effect named sfe1 mapped binding key regulator induced ectopic facial primordia enhancer activity craniofacial morphogenesis complementary mechanisms cis -</ 621 ). 3 regulate 3 </
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