Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx
Background<p>Previous studies have shown that the triglyceride glucose-body mass index (TyG-BMI) is associated with cardiovascular disease, stroke, and cognition. Its relationship with mental health remains underexplored. We aimed to investigate the association between TyG-BMI and mental healt...
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2025
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| _version_ | 1849927636694859776 |
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| author | Yanqin Li (499034) |
| author2 | Qi Gao (133189) Fan Luo (398044) Yuxin Lin (4042208) Ruqi Xu (15284441) Pingping Li (284244) Yuping Zhang (136067) Jiao Liu (135688) Hongrui Zhan (8439405) Licong Su (15284444) |
| author2_role | author author author author author author author author author |
| author_facet | Yanqin Li (499034) Qi Gao (133189) Fan Luo (398044) Yuxin Lin (4042208) Ruqi Xu (15284441) Pingping Li (284244) Yuping Zhang (136067) Jiao Liu (135688) Hongrui Zhan (8439405) Licong Su (15284444) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yanqin Li (499034) Qi Gao (133189) Fan Luo (398044) Yuxin Lin (4042208) Ruqi Xu (15284441) Pingping Li (284244) Yuping Zhang (136067) Jiao Liu (135688) Hongrui Zhan (8439405) Licong Su (15284444) |
| dc.date.none.fl_str_mv | 2025-11-25T05:11:13Z |
| dc.identifier.none.fl_str_mv | 10.3389/fpubh.2025.1672881.s003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Supplementary_file_1_L-shaped_association_of_triglyceride_glucose-body_mass_index_and_self-rated_mental_health_among_the_middle-aged_and_older_adults_a_national_cohort_study_in_China_docx/30703424 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Public Health and Health Services not elsewhere classified TyG-BMI insulin resistance mental health CHNS prospective cohort study |
| dc.title.none.fl_str_mv | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Background<p>Previous studies have shown that the triglyceride glucose-body mass index (TyG-BMI) is associated with cardiovascular disease, stroke, and cognition. Its relationship with mental health remains underexplored. We aimed to investigate the association between TyG-BMI and mental health in Chinese adults.</p>Methods<p>This study utilized data from the China Health and Nutrition Survey (CHNS), an ongoing longitudinal cohort. Participants aged ≥45 years who completed at least two survey rounds between 2009 and 2015 were included. The TyG index was calculated as ln [triglycerides (mg/dL) × fasting blood glucose (mg/dL) / 2]. BMI was calculated as weight (kg) divided by height squared (m<sup>2</sup>). The TyG-BMI was the product of the TyG index and BMI. Self-rated mental health was assessed using a composite score based on three CHNS questions regarding vitality, happiness, and optimism. Restricted cubic spline (RCS) curves and two-piecewise multivariable Cox hazard regression models, which were adjusted for sociodemographic, lifestyle, and cardiometabolic factors, were employed to explore the relationship between the TyG-BMI and self-rated mental health. Models were adjusted for sociodemographic, lifestyle, and cardiometabolic factors.</p>Results<p>Among 2,951 participants (47.6% male, median age 56.0 [25th, 75th percentile: 51, 64] years), the median TyG-BMI was 204.3 [25th, 75th percentile: 179.6, 231.8]. Over a median follow-up of 6.0 [2.0, 6.1] years, 1,026 (34.8%) incident was identified poor self-rated mental health. RCS curves indicated an L-shaped association between TyG-BMI and self-rated mental health (p for non-linear = 0.033), with an inflection point of 204.3. Below this threshold, each 10-unit increase in TyG-BMI was associated with a 6% decrease in self-rated mental health risk (adjusted hazard ratio [aHR] = 0.94, 95% confidence interval [CI]: 0.90–0.99). Each 1-standard deviation (SD) increase corresponded to a 20% risk reduction (aHR = 0.80, 95% CI: 0.67–0.96). Above the threshold, no significant association was observed. Subgroup and sensitivity analyses yielded consistent results.</p>Conclusion<p>This study revealed an L-shaped association between TyG-BMI and self-rated mental health in mentally healthy, middle-aged and older Chinese individuals. Our findings suggest that TyG-BMI may serve as an effective tool for enhancing the primary prevention of mental health.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_15622cb3b88d641dde87040848c25194 |
| identifier_str_mv | 10.3389/fpubh.2025.1672881.s003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30703424 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docxYanqin Li (499034)Qi Gao (133189)Fan Luo (398044)Yuxin Lin (4042208)Ruqi Xu (15284441)Pingping Li (284244)Yuping Zhang (136067)Jiao Liu (135688)Hongrui Zhan (8439405)Licong Su (15284444)Public Health and Health Services not elsewhere classifiedTyG-BMIinsulin resistancemental healthCHNSprospective cohort studyBackground<p>Previous studies have shown that the triglyceride glucose-body mass index (TyG-BMI) is associated with cardiovascular disease, stroke, and cognition. Its relationship with mental health remains underexplored. We aimed to investigate the association between TyG-BMI and mental health in Chinese adults.</p>Methods<p>This study utilized data from the China Health and Nutrition Survey (CHNS), an ongoing longitudinal cohort. Participants aged ≥45 years who completed at least two survey rounds between 2009 and 2015 were included. The TyG index was calculated as ln [triglycerides (mg/dL) × fasting blood glucose (mg/dL) / 2]. BMI was calculated as weight (kg) divided by height squared (m<sup>2</sup>). The TyG-BMI was the product of the TyG index and BMI. Self-rated mental health was assessed using a composite score based on three CHNS questions regarding vitality, happiness, and optimism. Restricted cubic spline (RCS) curves and two-piecewise multivariable Cox hazard regression models, which were adjusted for sociodemographic, lifestyle, and cardiometabolic factors, were employed to explore the relationship between the TyG-BMI and self-rated mental health. Models were adjusted for sociodemographic, lifestyle, and cardiometabolic factors.</p>Results<p>Among 2,951 participants (47.6% male, median age 56.0 [25th, 75th percentile: 51, 64] years), the median TyG-BMI was 204.3 [25th, 75th percentile: 179.6, 231.8]. Over a median follow-up of 6.0 [2.0, 6.1] years, 1,026 (34.8%) incident was identified poor self-rated mental health. RCS curves indicated an L-shaped association between TyG-BMI and self-rated mental health (p for non-linear = 0.033), with an inflection point of 204.3. Below this threshold, each 10-unit increase in TyG-BMI was associated with a 6% decrease in self-rated mental health risk (adjusted hazard ratio [aHR] = 0.94, 95% confidence interval [CI]: 0.90–0.99). Each 1-standard deviation (SD) increase corresponded to a 20% risk reduction (aHR = 0.80, 95% CI: 0.67–0.96). Above the threshold, no significant association was observed. Subgroup and sensitivity analyses yielded consistent results.</p>Conclusion<p>This study revealed an L-shaped association between TyG-BMI and self-rated mental health in mentally healthy, middle-aged and older Chinese individuals. Our findings suggest that TyG-BMI may serve as an effective tool for enhancing the primary prevention of mental health.</p>2025-11-25T05:11:13ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fpubh.2025.1672881.s003https://figshare.com/articles/dataset/Supplementary_file_1_L-shaped_association_of_triglyceride_glucose-body_mass_index_and_self-rated_mental_health_among_the_middle-aged_and_older_adults_a_national_cohort_study_in_China_docx/30703424CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307034242025-11-25T05:11:13Z |
| spellingShingle | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx Yanqin Li (499034) Public Health and Health Services not elsewhere classified TyG-BMI insulin resistance mental health CHNS prospective cohort study |
| status_str | publishedVersion |
| title | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx |
| title_full | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx |
| title_fullStr | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx |
| title_full_unstemmed | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx |
| title_short | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx |
| title_sort | Supplementary file 1_L-shaped association of triglyceride glucose-body mass index and self-rated mental health among the middle-aged and older adults: a national cohort study in China.docx |
| topic | Public Health and Health Services not elsewhere classified TyG-BMI insulin resistance mental health CHNS prospective cohort study |