Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy

<p>Supplementary Figure 3. The effect of FST or taxol treatment ovarian cancer proliferation and FST secretion, and the ability of a FST neutralization antibody to inhibit FST's effect on proliferation. A. PT340 and PT412 cells were treated with 200 ng/mL FST for 72h before cell counts we...

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Hovedforfatter: Alexander J. Cole (14971167) (author)
Andre forfattere: Santiago Panesso-Gómez (14971170) (author), Jaynish S. Shah (14971173) (author), Tonge Ebai (14971176) (author), Qi Jiang (14971179) (author), Ece Gumusoglu-Acar (14971182) (author), Maya G. Bello (14971185) (author), Anda Vlad (14960061) (author), Francesmary Modugno (14960046) (author), Robert P. Edwards (14971188) (author), Ronald J. Buckanovich (14971191) (author)
Udgivet: 2025
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author Alexander J. Cole (14971167)
author2 Santiago Panesso-Gómez (14971170)
Jaynish S. Shah (14971173)
Tonge Ebai (14971176)
Qi Jiang (14971179)
Ece Gumusoglu-Acar (14971182)
Maya G. Bello (14971185)
Anda Vlad (14960061)
Francesmary Modugno (14960046)
Robert P. Edwards (14971188)
Ronald J. Buckanovich (14971191)
author2_role author
author
author
author
author
author
author
author
author
author
author_facet Alexander J. Cole (14971167)
Santiago Panesso-Gómez (14971170)
Jaynish S. Shah (14971173)
Tonge Ebai (14971176)
Qi Jiang (14971179)
Ece Gumusoglu-Acar (14971182)
Maya G. Bello (14971185)
Anda Vlad (14960061)
Francesmary Modugno (14960046)
Robert P. Edwards (14971188)
Ronald J. Buckanovich (14971191)
author_role author
dc.creator.none.fl_str_mv Alexander J. Cole (14971167)
Santiago Panesso-Gómez (14971170)
Jaynish S. Shah (14971173)
Tonge Ebai (14971176)
Qi Jiang (14971179)
Ece Gumusoglu-Acar (14971182)
Maya G. Bello (14971185)
Anda Vlad (14960061)
Francesmary Modugno (14960046)
Robert P. Edwards (14971188)
Ronald J. Buckanovich (14971191)
dc.date.none.fl_str_mv 2025-11-25T13:04:28Z
dc.identifier.none.fl_str_mv 10.1158/1078-0432.30707171
dc.relation.none.fl_str_mv https://figshare.com/articles/figure/Figure_S3_from_Quiescent_Ovarian_Cancer_Cells_Secrete_Follistatin_to_Induce_Chemotherapy_Resistance_in_Surrounding_Cells_in_Response_to_Chemotherapy/30707171
dc.rights.none.fl_str_mv CC BY
info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv Cancer
Tumor Biology
Molecular and Cellular Biology
Therapeutic Research and Development
Cell Signaling
Autocrine-paracrine signaling
Drug Resistance
Novel mechanisms
Genitourinary Cancers
Translational Research
Tumor Heterogeneity
dc.title.none.fl_str_mv Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
dc.type.none.fl_str_mv Image
Figure
info:eu-repo/semantics/publishedVersion
image
description <p>Supplementary Figure 3. The effect of FST or taxol treatment ovarian cancer proliferation and FST secretion, and the ability of a FST neutralization antibody to inhibit FST's effect on proliferation. A. PT340 and PT412 cells were treated with 200 ng/mL FST for 72h before cell counts were performed. B (i) IHC images and (ii) FST+ cell bodies in OVSAHO tumor xenografts treated with or without taxol and stained with both Ki67 (Forangi Blue) and FST (Fast Red). C. Titer of the ability of the anti-FST neutralizing antibody to inhibit the effect of FST on cell growth.</p>
eu_rights_str_mv openAccess
id Manara_1610199f306cea01ab8c75516b542567
identifier_str_mv 10.1158/1078-0432.30707171
network_acronym_str Manara
network_name_str ManaraRepo
oai_identifier_str oai:figshare.com:article/30707171
publishDate 2025
repository.mail.fl_str_mv
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rights_invalid_str_mv CC BY
spelling Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to ChemotherapyAlexander J. Cole (14971167)Santiago Panesso-Gómez (14971170)Jaynish S. Shah (14971173)Tonge Ebai (14971176)Qi Jiang (14971179)Ece Gumusoglu-Acar (14971182)Maya G. Bello (14971185)Anda Vlad (14960061)Francesmary Modugno (14960046)Robert P. Edwards (14971188)Ronald J. Buckanovich (14971191)CancerTumor BiologyMolecular and Cellular BiologyTherapeutic Research and DevelopmentCell SignalingAutocrine-paracrine signalingDrug ResistanceNovel mechanismsGenitourinary CancersTranslational ResearchTumor Heterogeneity<p>Supplementary Figure 3. The effect of FST or taxol treatment ovarian cancer proliferation and FST secretion, and the ability of a FST neutralization antibody to inhibit FST's effect on proliferation. A. PT340 and PT412 cells were treated with 200 ng/mL FST for 72h before cell counts were performed. B (i) IHC images and (ii) FST+ cell bodies in OVSAHO tumor xenografts treated with or without taxol and stained with both Ki67 (Forangi Blue) and FST (Fast Red). C. Titer of the ability of the anti-FST neutralizing antibody to inhibit the effect of FST on cell growth.</p>2025-11-25T13:04:28ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/1078-0432.30707171https://figshare.com/articles/figure/Figure_S3_from_Quiescent_Ovarian_Cancer_Cells_Secrete_Follistatin_to_Induce_Chemotherapy_Resistance_in_Surrounding_Cells_in_Response_to_Chemotherapy/30707171CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307071712025-11-25T13:04:28Z
spellingShingle Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
Alexander J. Cole (14971167)
Cancer
Tumor Biology
Molecular and Cellular Biology
Therapeutic Research and Development
Cell Signaling
Autocrine-paracrine signaling
Drug Resistance
Novel mechanisms
Genitourinary Cancers
Translational Research
Tumor Heterogeneity
status_str publishedVersion
title Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
title_full Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
title_fullStr Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
title_full_unstemmed Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
title_short Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
title_sort Figure S3 from Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
topic Cancer
Tumor Biology
Molecular and Cellular Biology
Therapeutic Research and Development
Cell Signaling
Autocrine-paracrine signaling
Drug Resistance
Novel mechanisms
Genitourinary Cancers
Translational Research
Tumor Heterogeneity