Schematic overview of participant sampling timeline.
<p>(A) Individuals with a confirmed HIV-1 diagnosis started treatment during acute infection and were followed up in time. Blood sampling was performed at undetectable (UD; n = 9)) viral load (< 20 copies/mL) and again after 5 subsequent years (UD + 5; n = 5). (B) Individuals with a confirm...
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| अन्य लेखक: | , , , , , , , |
| प्रकाशित: |
2025
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| _version_ | 1849927626385260544 |
|---|---|
| author | Tine Struyve (22683295) |
| author2 | Marion Pardons (6407921) Jozefien De Clercq (17737815) Liesbet Termote (22683298) Laurens Lambrechts (10532207) Ytse Noppe (22683301) Mathias Lichterfeld (57148) Sofie Rutsaert (10667718) Linos Vandekerckhove (105574) |
| author2_role | author author author author author author author author |
| author_facet | Tine Struyve (22683295) Marion Pardons (6407921) Jozefien De Clercq (17737815) Liesbet Termote (22683298) Laurens Lambrechts (10532207) Ytse Noppe (22683301) Mathias Lichterfeld (57148) Sofie Rutsaert (10667718) Linos Vandekerckhove (105574) |
| author_role | author |
| dc.creator.none.fl_str_mv | Tine Struyve (22683295) Marion Pardons (6407921) Jozefien De Clercq (17737815) Liesbet Termote (22683298) Laurens Lambrechts (10532207) Ytse Noppe (22683301) Mathias Lichterfeld (57148) Sofie Rutsaert (10667718) Linos Vandekerckhove (105574) |
| dc.date.none.fl_str_mv | 2025-11-25T18:40:38Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.ppat.1013702.g001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Schematic_overview_of_participant_sampling_timeline_/30714913 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Medicine Neuroscience Biotechnology Evolutionary Biology Ecology Cancer Infectious Diseases Plant Biology Virology Computational Biology phorbol myristate acetate integration selection mechanisms xlink "> persistence small reservoir sizes treatment initiation timing clonal expansion contributes art ), irrespective individuals treated shortly reservoir persistence early reservoir persistence clonal expansion started treatment pma ), art initiation viral reservoir treated individuals inducible reservoir individuals treated 1 reservoir suggesting post proviruses integrated progressively enriched one year major barrier longitudinal analysis heterochromatin regions five years chronic cohorts cell compartment antiretroviral therapy already detected |
| dc.title.none.fl_str_mv | Schematic overview of participant sampling timeline. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>(A) Individuals with a confirmed HIV-1 diagnosis started treatment during acute infection and were followed up in time. Blood sampling was performed at undetectable (UD; n = 9)) viral load (< 20 copies/mL) and again after 5 subsequent years (UD + 5; n = 5). (B) Individuals with a confirmed HIV-1 diagnosis who began treatment during chronic infection, with blood sampling at undetectable viral load (UD; n = 10). (C) Individuals with a confirmed HIV-1 diagnosis who began treatment during chronic infection, with blood samples collected at varying durations on ART (UD + x, n = 57). Created in BioRender. Struyve, T. (2025) <a href="https://BioRender.com/cpljl4y" target="_blank">https://BioRender.com/cpljl4y</a>.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_161ef36d0fb0a30d057404f027bba0f4 |
| identifier_str_mv | 10.1371/journal.ppat.1013702.g001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30714913 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Schematic overview of participant sampling timeline.Tine Struyve (22683295)Marion Pardons (6407921)Jozefien De Clercq (17737815)Liesbet Termote (22683298)Laurens Lambrechts (10532207)Ytse Noppe (22683301)Mathias Lichterfeld (57148)Sofie Rutsaert (10667718)Linos Vandekerckhove (105574)BiochemistryMedicineNeuroscienceBiotechnologyEvolutionary BiologyEcologyCancerInfectious DiseasesPlant BiologyVirologyComputational Biologyphorbol myristate acetateintegration selection mechanismsxlink "> persistencesmall reservoir sizestreatment initiation timingclonal expansion contributesart ), irrespectiveindividuals treated shortlyreservoir persistence earlyreservoir persistenceclonal expansionstarted treatmentpma ),art initiationviral reservoirtreated individualsinducible reservoirindividuals treated1 reservoirsuggesting postproviruses integratedprogressively enrichedone yearmajor barrierlongitudinal analysisheterochromatin regionsfive yearschronic cohortscell compartmentantiretroviral therapyalready detected<p>(A) Individuals with a confirmed HIV-1 diagnosis started treatment during acute infection and were followed up in time. Blood sampling was performed at undetectable (UD; n = 9)) viral load (< 20 copies/mL) and again after 5 subsequent years (UD + 5; n = 5). (B) Individuals with a confirmed HIV-1 diagnosis who began treatment during chronic infection, with blood sampling at undetectable viral load (UD; n = 10). (C) Individuals with a confirmed HIV-1 diagnosis who began treatment during chronic infection, with blood samples collected at varying durations on ART (UD + x, n = 57). Created in BioRender. Struyve, T. (2025) <a href="https://BioRender.com/cpljl4y" target="_blank">https://BioRender.com/cpljl4y</a>.</p>2025-11-25T18:40:38ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.ppat.1013702.g001https://figshare.com/articles/figure/Schematic_overview_of_participant_sampling_timeline_/30714913CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307149132025-11-25T18:40:38Z |
| spellingShingle | Schematic overview of participant sampling timeline. Tine Struyve (22683295) Biochemistry Medicine Neuroscience Biotechnology Evolutionary Biology Ecology Cancer Infectious Diseases Plant Biology Virology Computational Biology phorbol myristate acetate integration selection mechanisms xlink "> persistence small reservoir sizes treatment initiation timing clonal expansion contributes art ), irrespective individuals treated shortly reservoir persistence early reservoir persistence clonal expansion started treatment pma ), art initiation viral reservoir treated individuals inducible reservoir individuals treated 1 reservoir suggesting post proviruses integrated progressively enriched one year major barrier longitudinal analysis heterochromatin regions five years chronic cohorts cell compartment antiretroviral therapy already detected |
| status_str | publishedVersion |
| title | Schematic overview of participant sampling timeline. |
| title_full | Schematic overview of participant sampling timeline. |
| title_fullStr | Schematic overview of participant sampling timeline. |
| title_full_unstemmed | Schematic overview of participant sampling timeline. |
| title_short | Schematic overview of participant sampling timeline. |
| title_sort | Schematic overview of participant sampling timeline. |
| topic | Biochemistry Medicine Neuroscience Biotechnology Evolutionary Biology Ecology Cancer Infectious Diseases Plant Biology Virology Computational Biology phorbol myristate acetate integration selection mechanisms xlink "> persistence small reservoir sizes treatment initiation timing clonal expansion contributes art ), irrespective individuals treated shortly reservoir persistence early reservoir persistence clonal expansion started treatment pma ), art initiation viral reservoir treated individuals inducible reservoir individuals treated 1 reservoir suggesting post proviruses integrated progressively enriched one year major barrier longitudinal analysis heterochromatin regions five years chronic cohorts cell compartment antiretroviral therapy already detected |