Validation of the MitoTracer algorithm.
<p>(A) Unsupervised hierarchical clustering of the VAF matrix of 24 informative MT mutations showed a clear clustering of BT142 and K562 cells for the MAESTER dataset. (B) Unsupervised hierarchical clustering of the VAF matrix of 47 informative MT mutations showed a clear clustering of GM11906...
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2025
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| Summary: | <p>(A) Unsupervised hierarchical clustering of the VAF matrix of 24 informative MT mutations showed a clear clustering of BT142 and K562 cells for the MAESTER dataset. (B) Unsupervised hierarchical clustering of the VAF matrix of 47 informative MT mutations showed a clear clustering of GM11906 and TF1 cells for mtscATAC-seq dataset. (C) Unsupervised hierarchical clustering of the VAF matrix of 23 informative MT mutations showed a clear clustering of C9, D6, and G10 hematopoietic cells for the scATAC-seq dataset. (D) Unsupervised hierarchical clustering of the VAF matrix of 31 informative MT mutations showed a clear clustering of cells by their patient origin for the SMART-seq2 dataset. (E) Unsupervised hierarchical clustering of the VAF matrix of 82 informative MT mutations showed a clear clustering of cells by their patient origin for the 10X scRNA-seq dataset.</p> |
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