Stimulating PV cells at nonsilencing levels during entire stimulus presentation or late phase V1 activity impairs discrimination performance, whereas stimulating during early phase V1 activity improves performance.

<p><b>A)</b> Example of grating stimuli separated by 90° for easy task (top), schematic of optogenetic manipulations activating only PV cells expressing ChR2 (middle), optogenetic stimulation timings for all four conditions aligned to stimulus onset (STIM ON) or offset (STIM OFF) (...

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Bibliographic Details
Main Author:	Lilia Kukovska (22683586) (author)
Other Authors:	Katharina A. Wilmes (22683589) (author), Natsumi Y. Homma (22683592) (author), Claudia Clopath (324706) (author), Jasper Poort (22683595) (author)
Published:	2025
Subjects:	Biochemistry Neuroscience Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified xlink "> inhibition three major factors strong competitive interactions photon imaging showed balanced cortical activity primary visual cortex sustained v1 activity combined optogenetic activation v1 cells captured moderate pv activation moderate activation visual discriminations expressing cells nonlinear activation dependent activation activation strength task difficulty stimulus onset perceptual discrimination difficult discriminations delineates conditions circuit model behavioral effects
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Stimulating PV cells at nonsilencing levels during entire stimulus presentation or late phase V1 activity impairs discrimination performance, whereas stimulating during early phase V1 activity improves performance.

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