Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
<p>Supplemental Movies 2a-2c: 22Rv1-NuclightGreen and SHP-77-NuclightRed mixed population co-cultures. Time-lapse movies of 22Rv1 cells (labeled with NuclightGreen) and SHP-77 cells (labeled with NuclightRed) co-cultured with T cells. Both the 22Rv1 and SHP-77 cells were plated at equal densit...
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2025
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| _version_ | 1849927639650795520 |
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| author | Jonathan Chou (14957015) |
| author2 | Emily A. Egusa (14962343) Sinan Wang (14962346) Michelle L. Badura (14962349) Fei Lee (14962352) Anil P. Bidkar (14962355) Jun Zhu (14962358) Tanushree Shenoy (14957003) Kai Trepka (14962361) Troy M. Robinson (14962364) Veronica Steri (14962367) Jiaoti Huang (14962370) Yuzhuo Wang (14962373) Eric J. Small (14962376) Emily Chan (14962379) Bradley A. Stohr (14962382) Alan Ashworth (14957030) Brant Delafontaine (14962385) Sylvie Rottey (14962388) Keegan S. Cooke (14962391) Nooshin Hashemi Sadraei (14962394) Brian Yu (14962397) Mark Salvati (14962400) Julie M. Bailis (14962403) Felix Y. Feng (14845891) Robert R. Flavell (9563200) Rahul Aggarwal (14960826) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Jonathan Chou (14957015) Emily A. Egusa (14962343) Sinan Wang (14962346) Michelle L. Badura (14962349) Fei Lee (14962352) Anil P. Bidkar (14962355) Jun Zhu (14962358) Tanushree Shenoy (14957003) Kai Trepka (14962361) Troy M. Robinson (14962364) Veronica Steri (14962367) Jiaoti Huang (14962370) Yuzhuo Wang (14962373) Eric J. Small (14962376) Emily Chan (14962379) Bradley A. Stohr (14962382) Alan Ashworth (14957030) Brant Delafontaine (14962385) Sylvie Rottey (14962388) Keegan S. Cooke (14962391) Nooshin Hashemi Sadraei (14962394) Brian Yu (14962397) Mark Salvati (14962400) Julie M. Bailis (14962403) Felix Y. Feng (14845891) Robert R. Flavell (9563200) Rahul Aggarwal (14960826) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jonathan Chou (14957015) Emily A. Egusa (14962343) Sinan Wang (14962346) Michelle L. Badura (14962349) Fei Lee (14962352) Anil P. Bidkar (14962355) Jun Zhu (14962358) Tanushree Shenoy (14957003) Kai Trepka (14962361) Troy M. Robinson (14962364) Veronica Steri (14962367) Jiaoti Huang (14962370) Yuzhuo Wang (14962373) Eric J. Small (14962376) Emily Chan (14962379) Bradley A. Stohr (14962382) Alan Ashworth (14957030) Brant Delafontaine (14962385) Sylvie Rottey (14962388) Keegan S. Cooke (14962391) Nooshin Hashemi Sadraei (14962394) Brian Yu (14962397) Mark Salvati (14962400) Julie M. Bailis (14962403) Felix Y. Feng (14845891) Robert R. Flavell (9563200) Rahul Aggarwal (14960826) |
| dc.date.none.fl_str_mv | 2025-11-24T22:44:18Z |
| dc.identifier.none.fl_str_mv | 10.1158/0008-5472.30699468 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/media/Supplementary_MovieS2a_from_Immunotherapeutic_Targeting_and_PET_Imaging_of_DLL3_in_Small-Cell_Neuroendocrine_Prostate_Cancer/30699468 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Therapeutic Research and Development Immuno-oncology Methods and Technology Drug Targets Cell surface receptor drug targets Genitourinary Cancers Prostate cancer Imaging Positron emission tomography (PET) Immunotherapy Preclinical Models Xenograft models |
| dc.title.none.fl_str_mv | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer |
| dc.type.none.fl_str_mv | Dataset Media info:eu-repo/semantics/publishedVersion dataset |
| description | <p>Supplemental Movies 2a-2c: 22Rv1-NuclightGreen and SHP-77-NuclightRed mixed population co-cultures. Time-lapse movies of 22Rv1 cells (labeled with NuclightGreen) and SHP-77 cells (labeled with NuclightRed) co-cultured with T cells. Both the 22Rv1 and SHP-77 cells were plated at equal densities and treated with either NT control BiTE®, AMG 757, or the PSMA-targeting HLE BiTE, AMG 160. T cells were added to each well at an E:T ratio of 10:1. Images were captured every 4 hours at 4x magnification for 5 days. a.22Rv1, SHP-77, and T cells co-cultured with NT control BiTE®. b.22Rv1, SHP-77, and T cells co-cultured with AMG 757. c.22Rv1, SHP-77, and T cells co-cultured with AMG 160.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_18b1c4f3c4f28df5f1d836278e011be7 |
| identifier_str_mv | 10.1158/0008-5472.30699468 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30699468 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate CancerJonathan Chou (14957015)Emily A. Egusa (14962343)Sinan Wang (14962346)Michelle L. Badura (14962349)Fei Lee (14962352)Anil P. Bidkar (14962355)Jun Zhu (14962358)Tanushree Shenoy (14957003)Kai Trepka (14962361)Troy M. Robinson (14962364)Veronica Steri (14962367)Jiaoti Huang (14962370)Yuzhuo Wang (14962373)Eric J. Small (14962376)Emily Chan (14962379)Bradley A. Stohr (14962382)Alan Ashworth (14957030)Brant Delafontaine (14962385)Sylvie Rottey (14962388)Keegan S. Cooke (14962391)Nooshin Hashemi Sadraei (14962394)Brian Yu (14962397)Mark Salvati (14962400)Julie M. Bailis (14962403)Felix Y. Feng (14845891)Robert R. Flavell (9563200)Rahul Aggarwal (14960826)CancerTherapeutic Research and DevelopmentImmuno-oncologyMethods and TechnologyDrug TargetsCell surface receptor drug targetsGenitourinary CancersProstate cancerImagingPositron emission tomography (PET)ImmunotherapyPreclinical ModelsXenograft models<p>Supplemental Movies 2a-2c: 22Rv1-NuclightGreen and SHP-77-NuclightRed mixed population co-cultures. Time-lapse movies of 22Rv1 cells (labeled with NuclightGreen) and SHP-77 cells (labeled with NuclightRed) co-cultured with T cells. Both the 22Rv1 and SHP-77 cells were plated at equal densities and treated with either NT control BiTE®, AMG 757, or the PSMA-targeting HLE BiTE, AMG 160. T cells were added to each well at an E:T ratio of 10:1. Images were captured every 4 hours at 4x magnification for 5 days. a.22Rv1, SHP-77, and T cells co-cultured with NT control BiTE®. b.22Rv1, SHP-77, and T cells co-cultured with AMG 757. c.22Rv1, SHP-77, and T cells co-cultured with AMG 160.</p>2025-11-24T22:44:18ZDatasetMediainfo:eu-repo/semantics/publishedVersiondataset10.1158/0008-5472.30699468https://figshare.com/articles/media/Supplementary_MovieS2a_from_Immunotherapeutic_Targeting_and_PET_Imaging_of_DLL3_in_Small-Cell_Neuroendocrine_Prostate_Cancer/30699468CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/306994682025-11-24T22:44:18Z |
| spellingShingle | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer Jonathan Chou (14957015) Cancer Therapeutic Research and Development Immuno-oncology Methods and Technology Drug Targets Cell surface receptor drug targets Genitourinary Cancers Prostate cancer Imaging Positron emission tomography (PET) Immunotherapy Preclinical Models Xenograft models |
| status_str | publishedVersion |
| title | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer |
| title_full | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer |
| title_fullStr | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer |
| title_full_unstemmed | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer |
| title_short | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer |
| title_sort | Supplementary MovieS2a from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer |
| topic | Cancer Therapeutic Research and Development Immuno-oncology Methods and Technology Drug Targets Cell surface receptor drug targets Genitourinary Cancers Prostate cancer Imaging Positron emission tomography (PET) Immunotherapy Preclinical Models Xenograft models |