Frequency response analysis of the commonly used indicator GCaMP6s, <i>k</i><sub><i>f</i></sub> = 0.0514, <i>k</i><sub><i>r</i></sub> = 7.6, <i>L</i> = 30.

Frequency response analysis of the commonly used indicator GCaMP6s, <i>k</i><sub><i>f</i></sub> = 0.0514, <i>k</i><sub><i>r</i></sub> = 7.6, <i>L</i> = 30.

<p>Results show that for higher frequency oscillations in firing rate, calcium dynamics cannot keep up, evident in the amplitude of <i>s</i> dominating the amplitude of calcium. Blue shows the total amount of calcium in the system, both bound and unbound. Orange depicts the unbound...

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Bibliographic Details
Main Author: Nicholas A. Rondoni (21573261) (author)
Other Authors: Fan Lu (490738) (author), Daniel B. Turner-Evans (1556602) (author), Marcella Gomez (11441993) (author)
Published: 2025
Subjects:
Biophysics
Cell Biology
Neuroscience
Biological Sciences not elsewhere classified
require significant data
propose potential applications
obscuring functional relationships
mechanistic modeling frameworks
control theoretic approach
art correlation scores
calcium imaging using
calcium imaging techniques
leveraging modeling frameworks
chemical reaction networks
true neuronal activity
predicting neuronal firing
neuronal firing rates
fluorescent calcium indicators
div >< p
neuronal activity
photon imaging
presented leveraging
neural networks
firing rate
use cases
spikefinder </
slow relative
retaining interpretability
powerful tool
new algorithm
meaningful metric
direct measure
animal ’
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Summary:<p>Results show that for higher frequency oscillations in firing rate, calcium dynamics cannot keep up, evident in the amplitude of <i>s</i> dominating the amplitude of calcium. Blue shows the total amount of calcium in the system, both bound and unbound. Orange depicts the unbound calcium ions themselves, while green shows the calcium ions bound to an indicator.</p>

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