Supplementary file 1_Hard to jump: host shifts appear unlikely in a T4-like phage evolved in the lab.docx

Supplementary file 1_Hard to jump: host shifts appear unlikely in a T4-like phage evolved in the lab.docx

Introduction<p>Bacteriophage therapy is emerging as a promising alternative to antibiotics, particularly in the face of rising antimicrobial resistance. However, concerns remain regarding host shifts, where therapeutic phages could evolve to infect and harm beneficial commensal bacteria. Under...

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Príomhchruthaitheoir:	Yu Ning (588573) (author)
Rannpháirtithe:	Enrique González-Tortuero (3514427) (author), Jeroen Wagemans (1743634) (author), Flor I. Arias-Sánchez (7329746) (author)
Foilsithe / Cruthaithe:	2025
Ábhair:	Clinical Microbiology phage therapy host shifts virulence infection phage therapeutics
Clibeanna:	Cuir clib leis Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!

Míreanna comhchosúla

Table 1_Hard to jump: host shifts appear unlikely in a T4-like phage evolved in the lab.xlsx
de réir: Yu Ning (588573)
Foilsithe / Cruthaithe: (2025)

Additional file 2 of Characterization of a novel Jumbo phage JP4 with potential to control pathogenic Escherichia coli
de réir: Kexin Zhang (301752)
Foilsithe / Cruthaithe: (2025)

Lab Materials
de réir: Rebecca Cree (19974267)
Foilsithe / Cruthaithe: (2025)

Table 1_Novel integrated approach modeling proanthocyanidins and bacteriophages to combat multidrug Salmonella Typhimurium in challenged broilers.docx
de réir: Hanan S. Al-Khalaifah (12864938)
Foilsithe / Cruthaithe: (2025)

Primers Used in This Study.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Bacterial Strains and Plasmids Used in This Study.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Oxidative stress resistance of the <i>yqhG</i> mutant.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Quantification of cell-associated PSMs in wild-type, Δ<i>yqhG</i>, and complemented strains. Cell-associated PSMs were extracted from bacterial pellets using 6 M guanidine hydrochloride and quantified by reversed-phase HPLC. The Δ<i>yqhG</i> mutant exhibited a significant reduction in surface-bound PSMs compared with the wild-type strain, whereas complementation restored PSM levels to near wild-type values. Data represent mean ± s.e.m. from three independent experiments. Statistical analysis was performed using one-way ANOVA; *<i>P</i> < 0.05, ns, not significant.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Surface motility of the <i>yqhG</i> mutant.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Membrane integrity in the <i>yqhG</i> mutant.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Biofilm formation in MRSA strains.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

YqhG is required for systemic virulence but not for <i>in vitro</i> growth.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Viable CFU counts following hydrogen peroxide exposure.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Amount of PSMs (μg/1mL culture) in MRSA wild-type, ΔyqhG, and complemented strains.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Colony diameter measurements from soft agar motility assays.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

SYTOX Green fluorescence measurements for membrane permeability assessment.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Crystal violet quantification of biofilm formation in MRSA wild-type, ΔyqhG, and complemented strains.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Spleen bacterial burden in mice infected with MRSA wild-type, ΔyqhG, and complemented strains.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Liver bacterial burden in mice infected with MRSA wild-type, ΔyqhG, and complemented strains.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Kidney bacterial burden in mice infected with MRSA wild-type, Δ<i>yqhG</i>, and complemented strains.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Heart bacterial burden in mice infected with MRSA wild-type, Δ<i>yqhG</i>, and complemented strains.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Survival data of BALB/c mice infected with MRSA wild-type, Δ<i>yqhG</i>, and complemented strains.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Optical density measurements of MRSA wild-type, Δ<i>yqhG</i>, and complemented strains during <i>in vitro</i> growth.
de réir: Jianhua Liao (1393228)
Foilsithe / Cruthaithe: (2025)

Identification of Septoria Nodorum Blotch Sensitivity Genes in Hard Winter Wheat: MS thesis - Oklahoma State University
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Foilsithe / Cruthaithe: (2025)

Table 1_Effects of resisted sprint training on sprint, jump, and change-of-direction performance in athletes: a systematic review and meta-analysis.docx
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Foilsithe / Cruthaithe: (2025)

Shifting the Narrative; Changing the World
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Foilsithe / Cruthaithe: (2025)

Evaluating docking approaches for prediction of cyclodextrin and cucurbituril host–guest complex structures
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Foilsithe / Cruthaithe: (2025)

Transcriptomic profiling of HIOs reveals viral replication and distinct host responses to EBOV and MARV infection.
de réir: Elizabeth Y. Flores (22676699)
Foilsithe / Cruthaithe: (2025)

<b>No effect of actual parasitism risk on egg rejection in two sympatric breeding cuckoo hosts</b>
de réir: Hanlin Yan (19840763)
Foilsithe / Cruthaithe: (2025)

Transcriptomic profiling of EBOV- and MARV-infected HCOs reveals viral load and shared and unique host responses.
de réir: Elizabeth Y. Flores (22676699)
Foilsithe / Cruthaithe: (2025)

Data phase shift for direct beam entering the interferometer
de réir: Stalin Beltran (22512557)
Foilsithe / Cruthaithe: (2025)

Data Sheet 1_An evolving role in the NICU: a study of the tasks, knowledge, skills, and practice demographics of the neonatal therapist.pdf
de réir: Alicia Fernandez-Fernandez (9139193)
Foilsithe / Cruthaithe: (2025)

Finland Confirms Historic Shift to Online Gambling License System by 2027
de réir: Tommi Korhonen (22683659)
Foilsithe / Cruthaithe: (2025)

Data Sheet 1_Interactions between the oyster larvae pathogen Vibrio ostreicida and the bivalve hosts Mytilus galloprovincialis and Magallana gigas.docx
de réir: Martina Leonessi (22686236)
Foilsithe / Cruthaithe: (2025)

Time series of concentration, best cross-correlation and shift of two stations at the Starzach site.
de réir: Yann Georg Büchau (22683667)
Foilsithe / Cruthaithe: (2025)

Supplementary Table S1 from Identifying Mechanisms of Resistance by Circulating Tumor DNA in EVOLVE, a Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer at Time of PARP Inhibitor Progression
de réir: Stephanie Lheureux (16797697)
Foilsithe / Cruthaithe: (2025)

Supplementary Table S2 from Identifying Mechanisms of Resistance by Circulating Tumor DNA in EVOLVE, a Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer at Time of PARP Inhibitor Progression
de réir: Stephanie Lheureux (16797697)
Foilsithe / Cruthaithe: (2025)

Supplementary Table S3 from Identifying Mechanisms of Resistance by Circulating Tumor DNA in EVOLVE, a Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer at Time of PARP Inhibitor Progression
de réir: Stephanie Lheureux (16797697)
Foilsithe / Cruthaithe: (2025)

Supplementary Table S4 from Identifying Mechanisms of Resistance by Circulating Tumor DNA in EVOLVE, a Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer at Time of PARP Inhibitor Progression
de réir: Stephanie Lheureux (16797697)
Foilsithe / Cruthaithe: (2025)

Supplementary Table S5 from Identifying Mechanisms of Resistance by Circulating Tumor DNA in EVOLVE, a Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer at Time of PARP Inhibitor Progression
de réir: Stephanie Lheureux (16797697)
Foilsithe / Cruthaithe: (2025)

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