Heatmap visualization of the data matrices, along with the detected domain boundaries and ARI values (bottom left corner).

<p>The five rows give various kinds of data matrices: the perfect block diagonal data (), the observed data with noise (), the KR-normalized data matrix (), the RWS-smoothed matrix with 3 steps (RWS3s), and the RWR-smoothed matrix with restart probability 0.1 (RWR0.1). The four columns show th...

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Bibliographic Details
Main Author:	Yongqi Liu (5464067) (author)
Other Authors:	Shili Lin (25251) (author)
Published:	2025
Subjects:	Medicine Genetics Biotechnology Developmental Biology Cancer Plant Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified topologically associated domains taking correct identification optimal parameter values dimensional hierarchical structure extensive analytical analyses downstream tad analyses current study provides achieve good performance xlink "> hi single cell hi real data applications assessment </ p answer biological questions based approaches prior data quality improvement performing random walks including random walk performing analyses biological questions data quality random walks simulation study performance success little improvement based approaches random walking random walk unrealistic scenario routinely generated range interactions practical guidelines necessary step little justification limited number end point empirical investigation developed accordingly chromosome three cautionary note better understanding &# 8220
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Heatmap visualization of the data matrices, along with the detected domain boundaries and ARI values (bottom left corner).

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