New Candidate Targets of AMP-Activated Protein Kinase in Murine Brain Revealed by a Novel Multidimensional Substrate-Screen for Protein Kinases

AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine kinase that is involved in the maintenance of energy homeostasis and recovery from metabolic stresses both at the cellular and whole body level. AMPK is found in all tissues examined so far, and a number of downstream targets h...

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Bibliografski detalji
Glavni autor:	Roland D. Tuerk (8660466) (author)
Daljnji autori:	Ramon F. Thali (8660469) (author), Yolanda Auchli (247893) (author), Helene Rechsteiner (8660472) (author), René A. Brunisholz (8660475) (author), Uwe Schlattner (18191) (author), Theo Wallimann (18196) (author), Dietbert Neumann (311099) (author)
Izdano:	2020
Teme:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Physiology Pharmacology Biotechnology Immunology Developmental Biology Inorganic Chemistry Infectious Diseases Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified appetite control AMP-Activated Protein Kinase murine brain lysates column method mass spectrometry Novel Multidimensional Substrate-Screen radiolabeled ATP candidate substrate proteins Recent work phosphorylation events energy homeostasis pilot screen New Candidate Kinase assays AMPK substrates body level Protein Kinases AMP-activated protein kinase brain-specific substrates kinase assays radiolabeled proteins SDS-PAGE Murine Brain Revealed AMPK targets MALDI 53 AMPK-specific phospho-spots
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New Candidate Targets of AMP-Activated Protein Kinase in Murine Brain Revealed by a Novel Multidimensional Substrate-Screen for Protein Kinases

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