Data Sheet 1_Intrinsic resistance to short-tailed azoles in the basal fungus Mucor lusitanicus: functional analysis of Cyp51 isoforms and amino acid substitutions.docx

Introduction<p>The basal fungus Mucor lusitanicus (Mlu) is a cause of mucormycosis, with limited treatment options due to intrinsic resistance to short-tailed azoles (fluconazole, voriconazole) and echinocandins. In silico analysis identified amino-acid-substitutions Y129F and V293A in the sub...

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Autore principale:	K. Rosam (22687364) (author)
Altri autori:	M. V. Keniya (22687367) (author), L.-M. Zenz (22687370) (author), C. Müller (2693209) (author), B. Sarg (22687373) (author), M. Stojanovic (15235538) (author), U. Binder (22687376) (author), B. C. Monk (22687379) (author), M. Lackner (3971021) (author)
Pubblicazione:	2025
Soggetti:	Microbiology azole AMR (antimicrobial resistance) mucormycoses mucormycetes lanosterol 14α demethylase Saccharomyces cerevisiae heterologous expression GMO (genetically modified organism)
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