S1 Data - Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity

S1 Data - Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity

<p><b>Source data for main and supporting figures</b>.</p> <p>(XLSX)</p>

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Rachel K. Meade (22216529) (author)
مؤلفون آخرون: Oyindamola O. Adefisayo (22216532) (author), Marco T. P. Gontijo (22216535) (author), Summer J. Harris (22216538) (author), Charlie J. Pyle (3617798) (author), Kaley M. Wilburn (12060476) (author), Alwyn M. V. Ecker (13184350) (author), Erika J. Hughes (22216541) (author), Paloma D. Garcia (22216544) (author), Joshua Ivie (22216547) (author), Michael L. McHenry (4672672) (author), Penelope H. Benchek (22216550) (author), Harriet Mayanja-Kizza (78637) (author), Jadee L. Neff (22216553) (author), Dennis C. Ko (7147757) (author), Jason E. Stout (9617361) (author), Catherine M. Stein (7359386) (author), Thomas R. Hawn (12261864) (author), David M. Tobin (8843690) (author), Clare M. Smith (8722557) (author)
منشور في: 2025
الموضوعات:
Medicine
Microbiology
Cell Biology
Genetics
Neuroscience
Immunology
Cancer
Science Policy
Infectious Diseases
Virology
Biological Sciences not elsewhere classified
recapitulate human phenotypic
outcomes vary widely
mouse chromosome 2
lead candidate underlying
increased bacterial burden
identify significant associations
placing human ctsz
derived tb granulomas
genetically diverse mice
tb susceptibility locus
tb disease severity
div >< p
tb susceptibility
tb severity
tb disease
ctsz </
conserved ctsz
pulmonary inflammation
previously mapped
ligand 1
known biomarker
genotypic variation
findings implicate
examine patient
decreased survival
cxcl1 axis
cxcl1 ),
cathepsin z
asymptomatic infection
associated macrophages
animal models
allows identification
ablation leads
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