Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx
Introduction<p>Dual-energy X‐ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis. Advances in 2D‐3D modelling to generate patient-specific 3D‐DXA models out of DXA images enable accurate volumetric representations of the femur, with potential for fracture risk prediction...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1852015591324385280 |
|---|---|
| author | Elham Alizadeh (22481428) |
| author2 | Carlos Ruiz Wills (18792223) Luis del Rio (303713) Silvana Di Gregorio (5658736) Ludovic Humbert (13449342) Jérôme Noailly (346615) |
| author2_role | author author author author author |
| author_facet | Elham Alizadeh (22481428) Carlos Ruiz Wills (18792223) Luis del Rio (303713) Silvana Di Gregorio (5658736) Ludovic Humbert (13449342) Jérôme Noailly (346615) |
| author_role | author |
| dc.creator.none.fl_str_mv | Elham Alizadeh (22481428) Carlos Ruiz Wills (18792223) Luis del Rio (303713) Silvana Di Gregorio (5658736) Ludovic Humbert (13449342) Jérôme Noailly (346615) |
| dc.date.none.fl_str_mv | 2025-10-23T05:35:09Z |
| dc.identifier.none.fl_str_mv | 10.3389/fbioe.2025.1673339.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Data_Sheet_1_Inelastic_mechanical_descriptors_for_osteoporotic_hip_fracture_discrimination_with_3D-DXA-based_nonlinear_finite_element_models_docx/30424621 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biotechnology biomechanics osteoporosis hip fracture discrimination 3D-DXA finite element |
| dc.title.none.fl_str_mv | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Introduction<p>Dual-energy X‐ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis. Advances in 2D‐3D modelling to generate patient-specific 3D‐DXA models out of DXA images enable accurate volumetric representations of the femur, with potential for fracture risk prediction when combined with finite element (FE) analyses. This study evaluates the ability of 3D‐DXA-based FE models to discriminate hip fractures under side-fall loading.</p>Methods<p>We used a retrospective case‐control study including 128 women, 64 of whom suffered a hip fracture. Mechanical descriptors, including strength, nonlinear deformation, residual displacement, and energy absorption under elastic‐plastic assumptions, were derived from force-displacement curves.</p>Results<p>The area under the receiver operating characteristic curve (AUROC) showed that strength and trabecular volumetric bone mineral density (vBMD) equally discriminated between fracture and control subjects. Residual displacement due to plastic strain accumulation at failure emerged as a key descriptor which, when combined with strength, significantly improved fracture discrimination (ΔAUROC = 0.11 vs. areal bone mineral density (aBMD); ΔAUROC = 0.08 vs. trabecular vBMD).</p>Discussion<p>These findings highlight the potential of 3D-DXA and FE modelling to improve fracture assessment within current DXA-based clinical workflows.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_24be2aef669c49ac6ea6ddaee682be2f |
| identifier_str_mv | 10.3389/fbioe.2025.1673339.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30424621 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docxElham Alizadeh (22481428)Carlos Ruiz Wills (18792223)Luis del Rio (303713)Silvana Di Gregorio (5658736)Ludovic Humbert (13449342)Jérôme Noailly (346615)Biotechnologybiomechanicsosteoporosiship fracture discrimination3D-DXAfinite elementIntroduction<p>Dual-energy X‐ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis. Advances in 2D‐3D modelling to generate patient-specific 3D‐DXA models out of DXA images enable accurate volumetric representations of the femur, with potential for fracture risk prediction when combined with finite element (FE) analyses. This study evaluates the ability of 3D‐DXA-based FE models to discriminate hip fractures under side-fall loading.</p>Methods<p>We used a retrospective case‐control study including 128 women, 64 of whom suffered a hip fracture. Mechanical descriptors, including strength, nonlinear deformation, residual displacement, and energy absorption under elastic‐plastic assumptions, were derived from force-displacement curves.</p>Results<p>The area under the receiver operating characteristic curve (AUROC) showed that strength and trabecular volumetric bone mineral density (vBMD) equally discriminated between fracture and control subjects. Residual displacement due to plastic strain accumulation at failure emerged as a key descriptor which, when combined with strength, significantly improved fracture discrimination (ΔAUROC = 0.11 vs. areal bone mineral density (aBMD); ΔAUROC = 0.08 vs. trabecular vBMD).</p>Discussion<p>These findings highlight the potential of 3D-DXA and FE modelling to improve fracture assessment within current DXA-based clinical workflows.</p>2025-10-23T05:35:09ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fbioe.2025.1673339.s001https://figshare.com/articles/dataset/Data_Sheet_1_Inelastic_mechanical_descriptors_for_osteoporotic_hip_fracture_discrimination_with_3D-DXA-based_nonlinear_finite_element_models_docx/30424621CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304246212025-10-23T05:35:09Z |
| spellingShingle | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx Elham Alizadeh (22481428) Biotechnology biomechanics osteoporosis hip fracture discrimination 3D-DXA finite element |
| status_str | publishedVersion |
| title | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx |
| title_full | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx |
| title_fullStr | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx |
| title_full_unstemmed | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx |
| title_short | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx |
| title_sort | Data Sheet 1_Inelastic mechanical descriptors for osteoporotic hip fracture discrimination with 3D-DXA-based nonlinear finite element models.docx |
| topic | Biotechnology biomechanics osteoporosis hip fracture discrimination 3D-DXA finite element |