Chloroquine boosted apoptosis induced by clozapine.

<p>MCF-7 cells were treated with 50 μM of clozapine for 72 h, with or without chloroquine, followed by measuring (A) cell proliferation via MTT assay, (B) intracellular ROS content by H<sub>2</sub>DCFDA uptake assay, and (C) apoptotic percentages by flow cytometry. (D) Total protei...

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主要作者:	Ya-Chun Fan (21567690) (author)
其他作者:	Shih-Chao Lin (3753646) (author), Po-Jung Lai (630383) (author), Pei-Chun Lai (10132949) (author), Germain Maurus (21567693) (author), Shiow-Yi Chen (160980) (author)
出版:	2025
主題:	Biochemistry Cell Biology Molecular Biology Physiology Pharmacology Biotechnology Immunology Developmental Biology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified western blotting analyses g1 phase arrest assess cell proliferation reduces cell viability induced cell death breast cancer cells term antipsychotic treatment ros ), apoptosis clozapine induces apoptosis reduces ros induced apoptosis antipsychotic drugs induced cytotoxicity similar ros ros plays ros generation induces autophagy used clonogenic upregulating p21 tumor effects therapeutic agent study investigates study demonstrates results show psychotic disorders psychiatric medication previous studies mtt assays flow cytometry findings suggest combining clozapine clozapine suppresses central role 231 cells
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Chloroquine boosted apoptosis induced by clozapine.

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