Chloroquine boosted apoptosis induced by clozapine.

Chloroquine boosted apoptosis induced by clozapine.

<p>MCF-7 cells were treated with 50 μM of clozapine for 72 h, with or without chloroquine, followed by measuring (A) cell proliferation via MTT assay, (B) intracellular ROS content by H<sub>2</sub>DCFDA uptake assay, and (C) apoptotic percentages by flow cytometry. (D) Total protei...

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Bibliographic Details
Main Author: Ya-Chun Fan (21567690) (author)
Other Authors: Shih-Chao Lin (3753646) (author), Po-Jung Lai (630383) (author), Pei-Chun Lai (10132949) (author), Germain Maurus (21567693) (author), Shiow-Yi Chen (160980) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Molecular Biology
Physiology
Pharmacology
Biotechnology
Immunology
Developmental Biology
Cancer
Hematology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
western blotting analyses
g1 phase arrest
assess cell proliferation
reduces cell viability
induced cell death
breast cancer cells
term antipsychotic treatment
ros ), apoptosis
clozapine induces apoptosis
reduces ros
induced apoptosis
antipsychotic drugs
induced cytotoxicity
similar ros
ros plays
ros generation
induces autophagy
used clonogenic
upregulating p21
tumor effects
therapeutic agent
study investigates
study demonstrates
results show
psychotic disorders
psychiatric medication
previous studies
mtt assays
flow cytometry
findings suggest
combining clozapine
clozapine suppresses
central role
231 cells
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