Total Synthesis of Rohitukine and Dysoline and Their Anticancer Analogues Flavopiridol and IIIM-290

Rohitukine is a naturally occurring piperidine alkaloid that has led to the discovery of several potent CDK9/T1 inhibitors, including flavopiridol and IIIM-290. (−)-(3<i>S</i>,4<i>R</i>)-1-Methyl-4-(2,4,6-trimethoxyphenyl)piperidin-3-ol serves as a crucial chiral intermediate...

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主要作者:	Madhusmita Nayak (720104) (author)
其他作者:	Kailas V. Kallurkar (22066212) (author), Tejaswi Somarowthu (20414975) (author), Jagadeesh Babu Nanubolu (567973) (author), Sandip B. Bharate (22066215) (author)
出版:	2025
主题:	Biophysics Biochemistry Genetics Molecular Biology Pharmacology Biotechnology Chemical Sciences not elsewhere classified closure equilibrium process >- selectride without >) diastereomer intermediate stable regioisomer dysoline several potent cdk9 chromatographic purification steps 4 -( 2 crucial chiral intermediate anticancer analogues flavopiridol chromatographic purification chiral alcohol ≥ 99 t1 inhibitors successfully employed ol serves including flavopiridol giving thermodynamically diastereoselective reduction developed method chromone nucleus c8 position >, 4 >)- 1
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Total Synthesis of Rohitukine and Dysoline and Their Anticancer Analogues Flavopiridol and IIIM-290

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