Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in Marine Microbulbifer Bacteria

Conserved biosynthetic gene clusters (BGCs) are often tied to the production of natural products that perform critical functions in an organism’s physiology and ecological interactions. Here, by phylogenetic analysis across the bacterial genus, we report the obligate conservation of a BGC in genomes...

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Main Author:	Yifan Tang (1269402) (author)
Other Authors:	Weimao Zhong (5519135) (author), Longping Fu (11727875) (author), Emmanuel Asante (22277327) (author), Anastasiia Kostenko (6939998) (author), F. N. U. Vidya (19935264) (author), Paige Mandelare-Ruiz (12041634) (author), Tamilore T. Adeogun (22277330) (author), Gabriel P. Anderson (22277333) (author), Benjamin E. Edmonds (22277336) (author), Oscar Fang (22277339) (author), Michelle Han (1618693) (author), Alia S. Hollingsworth (22277342) (author), Amna R. Ingham (22277345) (author), Carlyn R. Kirby (22277348) (author), Alice Landrum (22277351) (author), Connor R. Mack (22277354) (author), Nikki S. Nobari (22277357) (author), Emma J. Oswald (22277360) (author), Cecilia L. Polevoy (22277363) (author), Yasmin Sharifian (22277366) (author), Timothy J. So (22277369) (author), Joelee R. Stokes (22277372) (author), Reniya S. Thompson (22277375) (author), Rishabh Vuthamaraju (22277378) (author), Elaine C. Wang (22277381) (author), William H. Yang (4405492) (author), Alison E. Onstine (22277384) (author), Valerie J. Paul (307783) (author), Ronghu Wu (1643710) (author), Allegra T. Aron (14607873) (author), Vinayak Agarwal (1335897) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Genetics Evolutionary Biology Ecology Inorganic Chemistry Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified structure elucidated using perform critical functions nmr spectroscopy  natural product chemistry phylogenetic analysis across microbulbifer genomes regardless highly conserved copper natural products copper chelator undergraduate students provide hands phylogenomic identification pedagogic setting organism ’ often tied obligate conservation mass spectrometry georgia institute geographical dispersal genome mining ecological interactions common member bgc  bacterial phylogeny
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Phylogenomic Identification of a Highly Conserved Copper-Binding RiPP Biosynthetic Gene Cluster in Marine Microbulbifer Bacteria

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