Discovery and Characterization of Novel BLIMP‑1 Heterobifunctional Ligand-Directed Degraders

Discovery and Characterization of Novel BLIMP‑1 Heterobifunctional Ligand-Directed Degraders

B-lymphocyte-induced maturation protein 1 (BLIMP-1/PRDM1) is a master transcriptional repressor essential for terminal differentiation of activated B-cells into bone-marrow resident plasma cells. Multiple myeloma (MM) is a plasma cell malignancy wherein the BLIMP-1 regulon remains critical to suppor...

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Glavni autor: Bryan J. Simmons (22676881) (author)
Daljnji autori: Lynda Groocock (18218650) (author), Jesus Moreno (1312926) (author), David S. Peters (9079778) (author), Meredith E. Hughes (8822891) (author), Vijay Veeravalli (17374410) (author), Jennifer M. Crawford (1453204) (author), Matthew Chalkley (22676884) (author), Mark Griffith (22676887) (author), Melissa Plooster (22676890) (author), Bo Hu (126105) (author), Jim Gamez (22384825) (author), Jim Leisten (1562386) (author), Michael J. Barnes (22676893) (author), Jason Chinn (2500474) (author), Gauri Deb (3625370) (author), Hardik Modi (22676896) (author), Madhu Katepalli (22676899) (author), Dahlia Weiss (22384834) (author), Walter Won (22676902) (author), Zhenghang Sun (19474606) (author), Shan Yu (219591) (author), Cameron Reid (22676905) (author), Andrew F. Donnell (1893616) (author), Ling Li (38566) (author), Edmond R. Watson (19198701) (author), Sophie Perrin-Ninkovic (15067518) (author), Lihong Shi (481066) (author), Rama Krishna Narla (1562347) (author), Christoph W. Zapf (2019895) (author), Neil Bence (720479) (author), Antonia Lopez-Girona (8596584) (author), Jennifer R. Riggs (1278165) (author)
Izdano: 2025
Teme:
Biophysics
Biochemistry
Cell Biology
Genetics
Molecular Biology
Physiology
Pharmacology
Biotechnology
Immunology
Cancer
Hematology
Computational Biology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
underlie disease manifestation
tumor cell proliferation
expected antitumor response
elevated metabolic state
vivo mm models
directed degraders b
1 heterobifunctional ligand
directed degrader
activated b
terminal differentiation
multiple myeloma
immunoglobulin production
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