Discovery and Characterization of Novel BLIMP‑1 Heterobifunctional Ligand-Directed Degraders

B-lymphocyte-induced maturation protein 1 (BLIMP-1/PRDM1) is a master transcriptional repressor essential for terminal differentiation of activated B-cells into bone-marrow resident plasma cells. Multiple myeloma (MM) is a plasma cell malignancy wherein the BLIMP-1 regulon remains critical to suppor...

全面介绍

Saved in:

书目详细资料
主要作者:	Bryan J. Simmons (22676881) (author)
其他作者:	Lynda Groocock (18218650) (author), Jesus Moreno (1312926) (author), David S. Peters (9079778) (author), Meredith E. Hughes (8822891) (author), Vijay Veeravalli (17374410) (author), Jennifer M. Crawford (1453204) (author), Matthew Chalkley (22676884) (author), Mark Griffith (22676887) (author), Melissa Plooster (22676890) (author), Bo Hu (126105) (author), Jim Gamez (22384825) (author), Jim Leisten (1562386) (author), Michael J. Barnes (22676893) (author), Jason Chinn (2500474) (author), Gauri Deb (3625370) (author), Hardik Modi (22676896) (author), Madhu Katepalli (22676899) (author), Dahlia Weiss (22384834) (author), Walter Won (22676902) (author), Zhenghang Sun (19474606) (author), Shan Yu (219591) (author), Cameron Reid (22676905) (author), Andrew F. Donnell (1893616) (author), Ling Li (38566) (author), Edmond R. Watson (19198701) (author), Sophie Perrin-Ninkovic (15067518) (author), Lihong Shi (481066) (author), Rama Krishna Narla (1562347) (author), Christoph W. Zapf (2019895) (author), Neil Bence (720479) (author), Antonia Lopez-Girona (8596584) (author), Jennifer R. Riggs (1278165) (author)
出版:	2025
主题:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Physiology Pharmacology Biotechnology Immunology Cancer Hematology Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified underlie disease manifestation tumor cell proliferation expected antitumor response elevated metabolic state vivo mm models directed degraders b 1 heterobifunctional ligand directed degrader activated b terminal differentiation multiple myeloma immunoglobulin production
标签:	添加标签没有标签, 成为第一个标记此记录!

Discovery and Characterization of Novel BLIMP‑1 Heterobifunctional Ligand-Directed Degraders

相似书籍