scRNA-seq and snRNA-seq profiling of 26 melanoma samples.
<p>(A) t-SNE plots depicting the cell origins by seurat clusters (left panel), samples origin (middle panel) and tissue origin (left panel). (B-C) Boxplot showing the proportions of melanoma cells, T/NK cells and macrophages across PT, ECM and MBM. Statistical difference was calculated by the...
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2025
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| _version_ | 1849927642850000896 |
|---|---|
| author | Jingxin Zeng (18773484) |
| author2 | Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| author2_role | author author author author author |
| author_facet | Jingxin Zeng (18773484) Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jingxin Zeng (18773484) Ling Lin (57361) Yangyang Ma (6329852) Wenzhe Huang (446343) Quan Luo (1423180) Ju Wen (14784239) |
| dc.date.none.fl_str_mv | 2025-11-24T18:27:38Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336502.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/scRNA-seq_and_snRNA-seq_profiling_of_26_melanoma_samples_/30696969 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |
| dc.title.none.fl_str_mv | scRNA-seq and snRNA-seq profiling of 26 melanoma samples. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>(A) t-SNE plots depicting the cell origins by seurat clusters (left panel), samples origin (middle panel) and tissue origin (left panel). (B-C) Boxplot showing the proportions of melanoma cells, T/NK cells and macrophages across PT, ECM and MBM. Statistical difference was calculated by the Wilcoxon rank-sum test.</p> <p>(TIF)</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_283cdc3afcd00fa587f0a005692aa907 |
| identifier_str_mv | 10.1371/journal.pone.0336502.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696969 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | scRNA-seq and snRNA-seq profiling of 26 melanoma samples.Jingxin Zeng (18773484)Ling Lin (57361)Yangyang Ma (6329852)Wenzhe Huang (446343)Quan Luo (1423180)Ju Wen (14784239)Cell BiologyGeneticsNeuroscienceBiotechnologyImmunologyDevelopmental BiologyCancerHematologyVirologyBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedlimited treatment efficacyassociated tumor cellsadhesion genes (<nucleus rna sequencingmetastatic tumor subpopulation26 melanoma samplesstudy identifies mbmatcsmbm ecosystems showeddiv >< pmelanoma brain metastasismetastatic pathwaysbulk rnabrain metastasismelanoma patientsvalidation cohortsupregulated neuraltreg enrichmentremains lethalpotential activitynrg3 </ncam1 </mela3 ).lag3 </high riskhavcr2 </early stratificationclinical relevancecellular originscellular originbrain tropism>), suggesting1 </<p>(A) t-SNE plots depicting the cell origins by seurat clusters (left panel), samples origin (middle panel) and tissue origin (left panel). (B-C) Boxplot showing the proportions of melanoma cells, T/NK cells and macrophages across PT, ECM and MBM. Statistical difference was calculated by the Wilcoxon rank-sum test.</p> <p>(TIF)</p>2025-11-24T18:27:38ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0336502.s001https://figshare.com/articles/figure/scRNA-seq_and_snRNA-seq_profiling_of_26_melanoma_samples_/30696969CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306969692025-11-24T18:27:38Z |
| spellingShingle | scRNA-seq and snRNA-seq profiling of 26 melanoma samples. Jingxin Zeng (18773484) Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |
| status_str | publishedVersion |
| title | scRNA-seq and snRNA-seq profiling of 26 melanoma samples. |
| title_full | scRNA-seq and snRNA-seq profiling of 26 melanoma samples. |
| title_fullStr | scRNA-seq and snRNA-seq profiling of 26 melanoma samples. |
| title_full_unstemmed | scRNA-seq and snRNA-seq profiling of 26 melanoma samples. |
| title_short | scRNA-seq and snRNA-seq profiling of 26 melanoma samples. |
| title_sort | scRNA-seq and snRNA-seq profiling of 26 melanoma samples. |
| topic | Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </ |