scRNA-seq and snRNA-seq profiling of 26 melanoma samples.

scRNA-seq and snRNA-seq profiling of 26 melanoma samples.

<p>(A) t-SNE plots depicting the cell origins by seurat clusters (left panel), samples origin (middle panel) and tissue origin (left panel). (B-C) Boxplot showing the proportions of melanoma cells, T/NK cells and macrophages across PT, ECM and MBM. Statistical difference was calculated by the...

Disgrifiad llawn

Wedi'i Gadw mewn:

Manylion Llyfryddiaeth
Prif Awdur:	Jingxin Zeng (18773484) (author)
Awduron Eraill:	Ling Lin (57361) (author), Yangyang Ma (6329852) (author), Wenzhe Huang (446343) (author), Quan Luo (1423180) (author), Ju Wen (14784239) (author)
Cyhoeddwyd:	2025
Pynciau:	Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg

Samples & cell type composition in sc/snRNA-seq.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Marker genes in melanoma tumor cells across PT, ECM and MBM by sc/snRNA-seq.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Single cell RNA-seq and snRNA-seq profiling of the PTs (primary melanoma), ECMs (extracranial melanoma metastases) and MBMs (melanoma brain metastases) environments.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Fluvastatin inhibits the migration of melanoma A375 cells in a wound healing assay.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Discovery of therapeutic compounds targeting brain metastasis-associated tumor cells (MBMATCs) in high MBM-Index melanoma.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

The MBM-Index as an independent predictor of overall survival (OS) in melanoma.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Identification of melanoma brain metastasis-associated tumor cell subpopulations (MBMATCs).
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Tumor cell-specific transcriptomic features across PTs, ECMs and MBMs.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Immune landscape and CD8<sup>+</sup> T cell transition states in PTs, ECMs and MBMs.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Samples & cell type composition in melanoma tumor cells.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

AXL and MITF signature genes.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Identification of therapeutic drugs with high drug sensitivity for brain metastasis-associated tumor cells (MBMATCs) and high-brain metastasis (MBM) index patients.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

The enriched pathway by all transcripts differentially expressed between MBMATCs and other tumor cells, and between MBM-High and MBM-Low groups.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

The MBM-Index showed no significant correlation with clinicopathological features.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Interaction between MBMATCs and the immune microenvironment.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Pseudotime trajectory analysis of melanoma clusters Mela4 and Mela5.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

Immune cells profiling in PTs, ECMs and MBMs.
gan: Jingxin Zeng (18773484)
Cyhoeddwyd: (2025)

scRNA-seq, Oligodendrocyte-Lineage Meta-Atlas
gan: Nicholas Mikolajewicz (11242755)
Cyhoeddwyd: (2025)

Processed snRNA-seq data from wild-type and <i>Pink1</i>-deficient mouse gut
gan: Muhammad Junaid (14524523)
Cyhoeddwyd: (2025)

Processed single-cell RNA-seq dataset of cancer-associated fibroblasts in breast cancer patients receiving anti–PD-1 therapy
gan: Thang Pham (19938126)
Cyhoeddwyd: (2025)

Classification of Udai21 and the World Rice Core Collection based on ddRAD-Seq data.
gan: Hiroki Ikeda (510280)
Cyhoeddwyd: (2025)

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
gan: Matthia A. Karreman (15097355)
Cyhoeddwyd: (2025)

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
gan: Matthia A. Karreman (15097355)
Cyhoeddwyd: (2025)

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
gan: Matthia A. Karreman (15097355)
Cyhoeddwyd: (2025)

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
gan: Matthia A. Karreman (15097355)
Cyhoeddwyd: (2025)

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
gan: Matthia A. Karreman (15097355)
Cyhoeddwyd: (2025)

Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
gan: Matthia A. Karreman (15097355)
Cyhoeddwyd: (2025)

Supplementary Table 1 from Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis
gan: Nneoma Adaku (16991063)
Cyhoeddwyd: (2025)

Supplementary Table 2 from Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis
gan: Nneoma Adaku (16991063)
Cyhoeddwyd: (2025)

Supplementary Table 3 from Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis
gan: Nneoma Adaku (16991063)
Cyhoeddwyd: (2025)

<b>Engineered </b><b>VPg</b><b> </b><b>saRNA achieves cap-independent,</b><b> </b><b>low-immunogenic and precise</b><b> </b><b>encoding of therapeutic proteins </b><b>in vivo</b><b>.</b>
gan: Zunyong feng (22673801)
Cyhoeddwyd: (2025)

Data Sheet 1_The role of microRNAs and long non-coding RNAs in epigenetic regulation of T cells: implications for autoimmunity.pdf
gan: Soumil Prasad (22679354)
Cyhoeddwyd: (2025)

RNA-seq for gene annotation.
gan: Takuya Yamaguchi (4543105)
Cyhoeddwyd: (2025)

RNA-seq for gene expression analysis.
gan: Takuya Yamaguchi (4543105)
Cyhoeddwyd: (2025)

Data Sheet 1_MicroRNA identification and expression analysis of wheat thermo-sensitive male sterile line BNS366 for fertility transformation.zip
gan: Junpeng Chen (4927267)
Cyhoeddwyd: (2025)

Table S2 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors
gan: Joseph Toker (15399882)
Cyhoeddwyd: (2025)

Table S3 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors
gan: Joseph Toker (15399882)
Cyhoeddwyd: (2025)

Table S4 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors
gan: Joseph Toker (15399882)
Cyhoeddwyd: (2025)

Table S5 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors
gan: Joseph Toker (15399882)
Cyhoeddwyd: (2025)

Table S6 from Clinical Importance of the lncRNA <i>NEAT1</i> in Cancer Patients Treated with Immune Checkpoint Inhibitors
gan: Joseph Toker (15399882)
Cyhoeddwyd: (2025)

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